Early diagnosis of perinatal asphyxia by nucleated red blood cell
count: a case study.
(87,88) The finding of appreciable amount of nucleated red blood cells
in the placental circulation requires 6 to 12 hours or more, with umbilical blood, nucleated red blood cells
being the gold standard.
Negative prognostic indicators include semicoma/ coma, seizures, coagulopathy on presentation (PT>18s, PTT>30s), hypoglycemia unresponsive to treatment, elevated creatinine after 24 hours of therapy, hypothermia, and greater than 18 nucleated red blood cells
per 100 white blood cells.
Moreover, occasional metamyelocytes and nucleated red blood cells
were also noted.
This problem even applies to an excellent marker, such as the embryonic hemoglobin produced by nucleated red blood cells
, a subpopulation of fetal microchimeric cells present in the blood of pregnant women (9).
The presence of nucleated red blood cells
on the slide preparation
For example, a high take off of the WBC histogram can be caused by several elements, such as nucleated red blood cells
(nRBCs), giant platelets, platelet clumps, and even intra-cellular parasites from RBCs that get released during the lysing process.
Attempts to recover fetal cells focused for a time on fetal nucleated red blood cells
via analysis with fluorescence in situ hybridization and the PCR, but the disappointing results led to skepticism that NIPD would ever become a reality.
Basophilic stippling is often present and nucleated red blood cells
are generally seen (2).
Especially during the second wave, more numerous nucleated red blood cells
with decreased nuclear-to-cytoplasmic ratio were noted in the peripheral blood smears.
Q Basic hematology has the lab correct the WBC when there are six or more nucleated red blood cells
(nRBCs) when doing a manual differential.