nucleophile


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nucleophile

[′nü·klē·ə‚fīl]
(physical chemistry)
A species possessing one or more electron-rich sites, such as an unshared pair of electrons, the negative end of a polar bond, or pi electrons. Also known as electron donor.
References in periodicals archive ?
In this work, renewable and inexpensive CSO-based polyols with high potential were successfully synthesized by in-situ epoxidation then hydroxylation, with water as nucleophile and sulfuric acid as catalyst.
They appear to act in as adaptors: they bind to both the substrate and E2 simultaneously, and catalyze the ligation by bringing the nucleophile on the substrate into close proximity of the E2-ubiquitin thioester bond [4].
Initially, we synthesized the codonor-donor unit by a Horner-Wadsworth-Emmons reaction, using phosphonate of A,A-dimethylaminebenzyl 7 and Z-BuOK as base to generate the nucleophile specie, which subsequently reacted under stoichiometric control with 4,4'-diformyltriphenylamine 8 in a ratio of 1:1.
E-BODIPY compounds offer the potential for further modification when the substituting nucleophile is an ethynyl group, including nucleophilic addition to and polymerization of the compound at the alkyne site (Goze et al.
Even though aziridines are reactive compounds, the conditions for the nucleophile to attack on the aziridine ring are not conducive until the water leaves, and therefore it takes some time for the crosslink density to gain optimal strength which was reflected in the performance of the coatings during MEK double rubs and pencil hardness tests.
Enzyme active side is marked by a signature sequence HCXXGXXR where Cys104 is the enzymatic nucleophile and Arg110 coordinates with the phosphate group on phosohotyrosine [4].
A theoretical study of the role of an anionic palladium(0) complex in the cross-coupling of an aryl halide with an anionic nucleophile.
A good, more reactive, nucleophile is characterized by a lower value of [mu], [omega] and in opposite a good electrophile is characterized by a high value of [mu], [omega].
The nucleophilic attack by a nitrogen nucleophile, such as hydrazine, hydrazide and hydroxylamine, in carbonyl-containing functionalities, such as an aldehyde or ketone, has been an extensively explored orthogonal approach for protein labeling.
It is a nucleophile able to trap electrophilic mutagens in lipophilic compartments and generates a metabolite that facilitates natriuresis.
a 2300-fold increase in the rate of chloride elimination accompanies a 200-mV potential decrease), and (ii) lower potentials favor electrophile trapping (ketonization) over nucleophile trapping of the quinonemethide intermediate [2].
The possible explanations for these results included metal ions that may activate electrophile and nucleophile binding, and release electrons to modulate PO activity (Stryer 1995), or divalent cations that may change the secondary structure of certain peptides of PO to influence PO activity (Feng et al.