analogue

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Related to nucleoside analogue: ribavirin, Nucleotide analog, Nucleoside analogue reverse transcriptase inhibitors

analogue

(sometimes US), analog
1. 
a. a physical object or quantity, such as a pointer on a dial or a voltage, used to measure or represent another quantity
b. (as modifier): analogue watch
2. Biology an analogous part or organ
3. Chem
a. an organic chemical compound related to another by substitution of hydrogen atoms with alkyl groups
b. an organic compound that is similar in structure to another organic compound

analogue

(electronics)
(US: "analog") A description of a continuously variable signal or a circuit or device designed to handle such signals. The opposite is "discrete" or "digital".

Analogue circuits are much harder to design and analyse than digital ones because the designer must take into account effects such as the gain, linearity and power handling of components, the resistance, capacitance and inductance of PCB tracks, wires and connectors, interference between signals, power supply stability and more. A digital circuit design, especially for high switching speeds, must also take these factors into account if it is to work reliably, but they are usually less critical because most digital components will function correctly within a range of parameters whereas such variations will corrupt the outputs of an analogue circuit.

See also analogue computer.

analogue

The British and European spelling of analog.
References in periodicals archive ?
BOSTON -- Recent use of the nucleoside analogues abacavir and didanosine is associated with a significantly increased risk of myocardial infarction in HIV-infected individuals, whereas treatment with the thymidine analogues appears to convey no such risk, according to findings presented at the 15th Conference on Retroviruses and Opportunistic Infections.
Initial treatment regimens for chronic HBV consist of monotherapy with interferon-[alpha], pegylated interferon-[alpha], or nucleoside analogues.
Inhibitex is developing a series of phosphoramidate nucleoside analogues, or protides, which target the RNA-dependent RNA polymerase (NS5b) of HCV.
CYC682, a nucleoside analogue, has completed Phase I trials in the USA with evidence of potential clinical benefit and was shown in preclinical tests to be superior to the leading nucleoside analogue gemcitabine.
Sapacitabine appears to act through a dual mechanism that is unique among nucleoside analogues.
Nucleoside analogues, such as gemcitabine and ara-C, are effective treatments of solid and hematological cancers.
Study Suggests Synergy between ZADAXIN and Nucleoside Analogues
The results of this study, while preliminary, are significant in that they demonstrate the potential utility of Ziagen+Combivir in patients who have already been heavily treated with other nucleoside analogues," said Neil Graham, M.
In clinical studies, indinavir was studied alone and in combination with nucleoside analogues in HIV-infected people in various stages of disease.
A nucleoside analogue, 1592U89 acts by inhibiting the HIV reverse transcriptase, an enzyme which is essential to the replication of the virus.
These include three nucleoside analogue reverse transcriptase inhibitors, a protease inhibitor and an immunomodulator.
He is best known for his contributions as a key clinical investigator in the areas of alpha interferon treatment of chronic hepatitis and has been a major contributor to the medical literature on the use of nucleoside analogue therapy in patients with advanced hepatitis B.

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