nucleotidase


Also found in: Dictionary, Medical, Wikipedia.

nucleotidase

[‚nü·klē·ə′tī‚dās]
(biochemistry)
Any of a group of enzymes which split phosphoric acid from nucleotides, leaving nucleosides.
Mentioned in ?
References in periodicals archive ?
2001) Genetic basis of hemolytic anemia caused by pyrimidine 5' nucleotidase deficiency.
Furthermore, significant decrease in the expression level was also observed in a variety of proteins involved in ribosome processing (laminin receptor-like protein LAMRL5 (LAMR1P15)), membrane trafficking (copine-1 (CPNE1)), immune response (MHC Class I antigen (HLA-A)), DNA methylation (S-adenosylhomocysteine hydrolase (AHCY)), transcription and DNA repair (nuclear factor IV (XRCC5)), nucleotide metabolism (3'(2'),5-'bisphosphate nucleotidase 1 (BPNT1)) as well as apoptosis and cell cycle (PDCD6IP).
Other forms of 5prime nucleotidase be present in the cytoplasm and lysosomes and can be illustrious from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate[8].
The activities of pyrimidine nucleotidase (P5'N) and nicotinamide adenine dinucleotide synthase (NADS) are also modified in blood after Pb exposure.
In the Ap and N-9 treated groups the number of acrosome reacted cells were found to be high and it also caused agglutination of the sperms indicating the loss of intactness of the plasma membrane which was further supported by the significant reduction in the activity of membrane bound 5' nucleotidase and acrosin enzyme.
B-A reduces the elevated levels of serum alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), [gamma]-glutamyl transferase ([gamma]-GT), lactate dehydrogenase (LDH), 5' nucleotidase (5'ND).
Drug inactivation can result from Ara-CMP conversion into Ara-uracil by cytidine deaminase (cdd), or from dephosphorylation of Ara-CMP by cytoplasmic nucleotidase (3).
Laboratory results since her referral included vitamin B12 245 ng/L [reference interval (RI), 251911 ng/L], iron 370 ug/L (RI, 400-1450 [micro]g/L), anti-tTG IgA 13 AU (RI, 0-20 AU), and 5' nucleotidase 22.