is a fundamental protein in the extracellular pathway, since it produces adenosine from AMP and is communicated in a wide range of tissues (Zimmermann, 1992).
(2001) Genetic basis of hemolytic anemia caused by pyrimidine 5' nucleotidase
Among hydrolytic enzymes proteases phospholipases (PLA) were more screened pharmacologically whilst nucleases nucleotidases
and phosphatases (acidic as well as alkaline phosphatases) were less characterized (Matsui et al.
G., 1981,"determination of Serum 5' Nucleotidase
Wu et al., "A role for a lithium-inhibited Golgi nucleotidase
in skeletal development and sulfation," Proceedings of the National Academy of Sciences of the United States of America, vol.
Furthermore, significant decrease in the expression level was also observed in a variety of proteins involved in ribosome processing (laminin receptor-like protein LAMRL5 (LAMR1P15)), membrane trafficking (copine-1 (CPNE1)), immune response (MHC Class I antigen (HLA-A)), DNA methylation (S-adenosylhomocysteine hydrolase (AHCY)), transcription and DNA repair (nuclear factor IV (XRCC5)), nucleotide metabolism (3'(2'),5-'bisphosphate nucleotidase
1 (BPNT1)) as well as apoptosis and cell cycle (PDCD6IP).
Other forms of 5prime nucleotidase
be present in the cytoplasm and lysosomes and can be illustrious from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.
There's albumin and globulin and aspartate transaminase, and 5' nucleotidase
, gamma glutamyl transpeptidase and lactate dehydrogenase, and alanine transaminases.
The activities of pyrimidine nucleotidase
(P5'N) and nicotinamide adenine dinucleotide synthase (NADS) are also modified in blood after Pb exposure.
EIF2AK2 is involved in mRNA translation and inflammasome activation , NAMPT is a key [NAD.sup.+] producing gene , and NT5C3 is an antiviral pyrimidine nucleotidase
Pinsky, "Increased CD39 nucleotidase
activity on microparticles from patients with idiopathic pulmonary arterial hypertension," PLoS One, vol.
For example, [gamma] glutamyl transferase and 5'nucleotidase
have high activities in bile, and are therefore low (<5th percentile) activities in biliary atresia due to restriction of bile flow.