nucleotide excision repair


Also found in: Acronyms, Wikipedia.

nucleotide excision repair

[¦nü·klē·ə‚tīd ik′sizh·ən rē‚per]
(cell and molecular biology)
A five-step pathway that is the major repair system for removing bulky lesions in deoxyribonucleic acid.
References in periodicals archive ?
Centrin2 modulates homologous recombination and nucleotide excision repair in Arabidopsis.
base excision repair and nucleotide excision repair (NER) (7, 8), which produce, respectively, 8-OH-Gua and 8-OHdGuo.
He is specifically interested in transcription factor, DNA methyl transferases and nucleotide excision repair.
Although there are five types of DNA repair performed by mammalian cells, the investigators then specifically measured the amount of repair performed by one type called nucleotide excision repair.
This damage is usually repaired by a process called nucleotide excision repair, which cuts out and replaces sections of damaged DNA.
Considerable attention has focused on interference with DNA repair by inorganic arsenic, especially the nucleotide excision repair (NER) pathway, whereas less is known about the effect of arsenic on the induction of DNA damage by other agents.
The poster presentation is entitled "Cytotoxicity of novel alkylating anthraquinones in cells with DNA Nucleotide Excision Repair and DNA Mismatch Repair defects," and focuses on structure-activity studies on the company's novel technology for targeting and irreversibly binding to DNA / DNA processing enzymes.
Various in vitro trials have shown that trabectedin's activity depends at least partly on the nucleotide excision repair (NER) mechanism.
Millikan of the University of North Carolina at Chapel Hill and his colleagues document findings suggesting that specific combinations of polymorphisms on certain nucleotide excision repair (NER) genes may modify the risk of breast cancer in black women who smoke.
Brostallicin induces DNA damage measured by histone H2AX phosphorylation independently of the nucleotide excision repair pathways.