nucleotide excision repair


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nucleotide excision repair

[¦nü·klē·ə‚tīd ik′sizh·ən rē‚per]
(cell and molecular biology)
A five-step pathway that is the major repair system for removing bulky lesions in deoxyribonucleic acid.
References in periodicals archive ?
What dose of a toxin is needed to overwhelm the average person's nucleotide excision repair capacity?
Within the nucleotide excision repair pathway, the excision repair cross-complementing group 1 protein (ERCC1) has a critical and rate-limiting role of recognizing and helping remove DNA adducts.
The center of the book focuses on interventions in oncology and their relationship to DNA maintenance processes, including alkylating chemotherapeutics, MGMT, assessment of mismatch repair efficacy to predict the genesis or progression of cancer, and targeted base excision and nucleotide excision repair.
Collaborative Dynamic DNA Scanning by Nucleotide Excision Repair Proteins Investigated by Single-Molecule Imaging of Quantum-DotLabeled Proteins.
This process, widespread in nature, is called nucleotide excision repair (NER).
Hepatitis B virus X protein inhibits nucleotide excision repair.
Abstract: Xeroderma pigmentosum (XP) occurs due to molecular defects in the genes involved in nucleotide excision repair of ultraviolet-induced DNA lesions.
Therapeutic inhibition of DNA repair in cancer cells can sensitize the cancer cells towards the chemotherapeutics or else they can function as synthetic lethal approach for treatment of cancers with DNA repair defects such as Nucleotide Excision Repair (NER) of Xeroderma pigmentosum.
The researchers demonstrated that B-cells are deficient in one of the main DNA repair pathways, known as Nucleotide Excision Repair.
1993) that are removed primarily by the nucleotide excision repair pathway (Bootsma and Hoeijmakers, 1994; Zheng et al.
The most common defect in xeroderma pigmentosum is an autosomal recessive genetic defect in which nucleotide excision repair (NER) enzymes are mutated, leading to a reduction in or elimination of NER.