Pathogenesis of sciatic pain: role of herniated nucleus pulposus
and deformation of spinal nerve root and dorsal root ganglion.
Secondly, in adults, it involves annulus fibrosus in addition to nucleus pulposus
. Thirdly, it is mainly a degenerative process; however, it can also reflect a systemic disease.
Efficacy of a new navigable percutaneous disc decompression device (L'DISQ) in patients with herniated nucleus pulposus
related to radicular pain.
* 4th stage is sequestration where nucleus pulposus
breaks through the annulus fibrosus and moves outside the disc.
Scientists trying to find early therapy options to fight degenerative disc disease have shown considerable interest in harnessing stem cells to restore nucleus pulposus
Likhitpanichkul et al., "Inflammatory kinetics and efficacy of anti-inflammatory treatments on human nucleus pulposus
cells," Spine, vol.
After that, many groups isolated and identified MSCs from the nucleus pulposus
, annulus fibrosus, and cartilage endplate [10, 11, 23-30].
MRI confirmed removal of the nucleus pulposus
and showed distension of the dura mater (Figure 3).
Total ADC values of L1 intervertebral discs in Groups A (0.00154 [+ or -] 0.00008), B (0.00130 [+ or -] 0.00005), C (0.00122 [+ or -] 0.00007), and D (0.00107 [+ or -] 0.00007) significantly decreased with age ( P < 0.01); nucleus pulposus
ADC values of L1 intervertebral discs in Groups A (0.00164 [+ or -] 0.00005), B (0.00156 [+ or -] 0.00007), C (0.00147 [+ or -] 0.00008), and D (0.00140 [+ or -] 0.00007) significantly decreased with age ( P < 0.01); annulus fibrosis ADC values of L1 intervertebral discs in Groups A (0.00129 [+ or -] 0.00014), B (0.00110 [+ or -] 0.00011), C (0.00095 [+ or -] 0.00009), and D (0.00082 [+ or -] 0.00012) significantly decreased with age ( P < 0.01).
All affected disc spaces show low signal on both [T.sub.1] and [T.sub.2] weighted images because of loss of hydration of nucleus pulposus
Development of a tissue-engineered intervertebral disc, where nucleus pulposus
implant will be anchored to annulus fibrosus and the end plate by tissue-engineered matrix, may have advantages over techniques.
Earlier studies show that leakage of nucleus pulposus
(NP) out of the disc after intervertebral disc herniation is associated with a local release of many substances including interleukin 1[beta](IL-1[beta]), tumor necrosis factor (TNF), and colony stimulating factor 1 (Csf1) [1-4].