null cell


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null cell

[′nəl ‚sel]
(immunology)
A lymphocyte without T- or B-cell markers on its surface.
References in periodicals archive ?
Assuming that categories defined by SF-1 staining (Pit-1/ ACTH-negative, ie, gonadotroph adenomas), ACTH-staining (Pit-1/SF-1-negative, ie, corticotroph adenomas), and Pit-1/SF-1/ACTH-negative tumors (IHC null cell adenoma, see discussion) can be studied with only the screening antibodies and review of clinical and serologic history, approximately one-third fewer stains might be used in the characterization of pituitary adenoma in our system, given the prevalence of adenoma subtypes noted in the current series (Tables 4 and 5, compare Total Stains, Prior System, and Total Stains, New Algorithm).
In a study by Benharroch et al, CD 3 was negative in more than 75% of ALCL ALK positive19, with great majority of ALCLs express one or more T-cell antigens and/or NK cell antigens but due to loss of several pan T-cell antigens, some cases may had an apparent null cell" phenotype.
SDS: Sodium dodecyl sulphate; gfp: Green fluorescent protein gene; epo: Erythropoietin gene, EPO; Null cell: Dictyostelium discoideum cell, Ax-2 strain without transformation; Dictyostelium-gfp: Dictyostelium discoideum transformed with plasmid containing gfp gene; Dictyostelium-epo: Dictyostelium discoideum transformed with plasmid containing epo gene.
Histologically, pituitary adenomas are classified as basophilic, eosinophilic, and null cell; each has a host of different subtypes whose classification is based on specific ultrastructural and immunophenotypic features.