A novel STAT3 inhibitor, S31-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy.
Mice lacking the matrix metalloproteinase-9 gene reduce renal interstitial fibrosis in obstructive nephropathy.
Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy.
Obviously, nondilated obstructive nephropathy
with acute renal failure developed, therefore, signs of obstructive nephropathy
such as hydronephrosis or hydroureter were not found.
Macrophage phenotype and renal fibrosis in obstructive nephropathy
8 Second, large renal cell neoplasms, especially those which are centered in renal medulla or urothelial carcinoma, may be associated with chronic obstructive nephropathy, as described in detail below.
OBSTRUCTIVE NEPHROPATHY, REFLUX NEPHROPATHY, HYDRONEPHROSIS, AND CHRONIC PYELONEPHRITIS
14,15) Obstructive nephropathy represents renal changes due to urinary obstruction, regardless of cause, anywhere between the ureteropelvic junction to the urethra.
During chronic obstructive nephropathy, it is fibrogenic process that critically leads to permanent loss of the normal structural and functional integrity of the kidney (Chevalier et al.
All these indicate that PF might be a good candidate to combat renal fibrosis induced by obstructive nephropathy.
Given the frequency of BPH in elderly men and the increasing number of elderly men in the United States, the potential for increasing numbers of patients with obstructive nephropathy is significant.
Excluding congenital obstructive uropathy, a total of 4,869 patients with the diagnosis of obstructive nephropathy began ESRD treatment in the United States from 1989 to 1993.