ochronosis


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ochronosis

[‚ō·krə′nō·səs]
(medicine)
A blue or brownish-blue discoloration of cartilage and connective tissue, especially around joints, caused by melanotic pigment.
References in periodicals archive ?
Ochronosis is a syndrome caused by the accumulation of homogentisic acid (HGA) in connective tissues.
It has been suggested that the delayed appearance of ochronosis is associated with decreased renal clearance of HGA with aging.
Ochronosis is a rare metabolic disorder that affects peripheral joints as well as spine and soft tissue.
2), (3) Furthermore, in this disease, excessive HGA is converted to a polymeric melanin-like pigment that binds to all connective tissues in a pathophysiological process called ochronosis.
However, in cases of significant degenerative arthritis, joint replacement can be performed with anticipation of outcomes comparable to osteoarthritic patients without ochronosis.
Ochronosis of prostate presenting as advanced carcinoma.
It is well known that use of mercury or excessive hydroquinone in skin care products have resulted in serious health complications and skin rash known as ochronosis.
We report the case of a male patient, aged 40 years, with knee and lumbar spine arthropathy secondary to confirmed ochronosis.
Other rare causes of AS includes: Subacute Lupus Erythematosus (SLE), rheumatoid arthritis, homozygous type II hyperlipidemia, Paget's disease, infective endocarditis, ochronosis and radiation.
While exogenous ochronosis is seen in about 42% of South African women and 15% of South African men using hydroquinone, the condition is very rare in the United States.
Localized exogenous ochronosis (blue-black hyper pigmentation) of the face developed in a fifty year-old black woman who had used a proprietary bleaching cream containing 2% hydroquinone up to six times daily for about two and half years.
Among the possible causes of black thyroid are minocycline-induced pigmentation, hemochromatosis, ochronosis, mucoviscidosis, ceroid storage disease, bruising, and hemorrhage.