Estradiol

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Related to oestradiol: oestrogen, progesterone

estradiol

[‚es·trə′dī‚ȯl]
(biochemistry)
C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.

Estradiol

 

C18H24O2, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

References in periodicals archive ?
There was no significant difference in FSH and oestradiol levels when we compared SHypo patients with controls (Table 1, Fig 2 and Fig.
With menstruation, patients' treatment began with 2 oestradiol patches/2 days (Estradot[R] 75 mg; Novartis, Spain).
Hormonal contraceptives containing ethinyl oestradiol as Norvir may reduce the effectiveness of these medicines.
The study adds evidence to a previous research, which demonstrated higher levels of the female sex hormone oestradiol in women who entered menarche before the age of 12.
Sex hormone binding globulin (SHBG) is a glycoprotein possessing high affinity binding for 17 beta-hydroxysteriod hormones such as testosterone and oestradiol.
Main outcome measures were: anthropometric measures, body composition, leptin, adiponectin, TNF-alpha, homocysteine, C-reactive protein, glucose, insulin, lipid profile and oestradiol serum levels, Kupperman index and Cervantes Scale.
Middle-aged women prone to several hot flushes have up to 40% less oestradiol, a form of oestrogen.
Photocatalytic degradation of 17(3-oestradiol, oestradiol, and 17[alpha]-ethynyloestradiol in water monitored using fluorescence spectroscopy.
The extent of such evaluation is debatable and includes serum human chorionic gonadotropin (hCG), luteinising hormone, testosterone, oestradiol, thyroid function and liver function tests.
Summary of sorption parameters for oestradiol and estrone derived from the multiple-concentration isotherms in Matawhero soil amended with 3 types of biochar (BC) and in soil alone CC, Corncob; PSD, pine sawdust; GW, green waste.
Compared to postmenopausal women, the reduction in serum oestradiol by aromatase inhibition increases fracture risk by around 2.
Women who used NSAIDs at least 15 days per month had significantly lower levels of oestradiol compared with women with no NSAID use.