Estradiol

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Related to oestradiol: oestrogen, progesterone

estradiol

[‚es·trə′dī‚ȯl]
(biochemistry)
C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.

Estradiol

 

C18H24O2, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

References in periodicals archive ?
In vitro studies have shown that an increase in intracellular calcium induced by Ach could be modulated by oestradiol in LHRH neurons through specific receptor sites at the plasma membrane [26]; these results could help to partially explain how oestradiol exerts its rapid, negative feedback actions on GnRH and LH secretion in female reproduction.
In general, patients at risk to develop OHSS are patients with AMH levels above 3.3 ng/dL [8, 9], age below 30 years, low BMI, polycystic ovaries syndrome (PCOS), previous OHSS, E2 levels more than 3000 pg/mL in the day of trigger, rapidly rising of oestradiol levels during stimulation and number of oocyte collected >15.
Leptin was estimated by kits obtained from Diagnostic Automation, Inc., CA while anterior pituitary hormones (follicle stimulating hormone (FSH), luteinizing hormone (LH) and prolactin) and sex hormones (testosterone and oestradiol) were estimated using kits obtained from Immunometrics UK Ltd.
There was no significant difference in FSH and oestradiol levels when we compared SHypo patients with controls (Table 1, Fig 2 and Fig.3).
The low intensity of oestrus in buffaloes may be due to low circulating concentrations of 17-p oestradiol in comparison with dairy cattle (Seren et al., 1995).
Conventional measures to assess a woman's potential to produce eggs, such as measurement of follicle stimulating hormone (FSH), oestradiol, inhibin B.
Oestradiol concentration and the development of the uterine oxytocin receptor and oxytocin-induced PGF release in ewes.
Anamnesis revealed mismating and estrogen injections (Oestradiol valerate) in two subsequent heats, after which female did not show heat for 1 year.
Perinatal exposure to oestradiol and bisphenol A alters the prostate epigenome and increases susceptibility to carcinogenesis.
The study adds evidence to a previous research, which demonstrated higher levels of the female sex hormone oestradiol in women who entered menarche before the age of 12.
Main outcome measures were: anthropometric measures, body composition, leptin, adiponectin, TNF-alpha, homocysteine, C-reactive protein, glucose, insulin, lipid profile and oestradiol serum levels, Kupperman index and Cervantes Scale.