Estrone

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Related to oestrone: estradiol

estrone

[′e‚strōn]
(biochemistry)
C18H22O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; functions the same as estradiol.

Estrone

 

C18H22O2, a female sex hormone of the estrogen group. Estrone occurs as colorless crystals with a melting point of 259°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +170°.

Estrone was first isolated in 1929 from the urine of pregnant women by A. Butenandt and the American biochemist E. Doisy. Specific sources rich in the hormone are the urine and testes of stallions. The hormone is readily converted both metabolically and chemically into estradiol, a hormone that has higher estrogenic activity. Estrone is found not only in animals and humans, but also in certain fruits, such as the coconut, apple, and pomegranate. Because its structure is so simple, many methods for the complete chemical synthesis of estrone have been developed. The most economical of these was suggested by the Soviet scientist I. V. Torgov in 1962.

Estrone has important physiological functions (see).

References in periodicals archive ?
Low levels of 17-[beta]-oestradiol, oestrone and testosterone correlate with severe evaporative dysfunctional tear syndrome in postmenopausal women: a case-control study.
Tibolone is also a sulphatase inhibitor, blocking conversion of oestrone sulphate to oestrone, as well as stimulating local sulphotransferase activity.
Ethnic differences in post-menopausal plasma oestrogen levels: high oestrone levels in Japanese-American women despite low weight.
Comparison of coumestrol and oestrone activity ovari-ectomized on some lipid metabolism indices in normal and ovaiectomized female rats.
Components include the natural oestrogens oestradiol, oestrone and oestriol, plus oestrogens from the urine of pregnant mares.