esthesioneuroblastoma

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esthesioneuroblastoma

[es¦thē·zē·ō¦nu̇r·ō‚bla′stō·mə]
(medicine)
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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Olfactory neuroblastoma: The 22-year experience at one comprehensive cancer center.
Benito, "Esthesioneuroblastoma (olfactory neuroblastoma) with ectopic ACTH syndrome: A multidisciplinary case presentation from the Joan Karnell Cancer Center of Pennsylvania Hospital," The Oncologist, vol.
Olfactory neuroblastoma (ONB), also known as Esthesioneuroblastoma, is a rare but distinct malignant neuroectodermal tumor arising from the olfactory epithelium of roof of nasal cavity and cribriform plate.
This case was originally classified by an outside hospital as olfactory neuroblastoma but was reclassified as melanoma on re-review and additional immunohistochemical staining (hematoxylin-eosin, original magnifications X100 [A, C, D, and E] and X200 [B]).
Olfactory neuroblastoma (ONB) is a malignant neoplasm thought to arise from the olfactory membrane of the sinonasal tract.
Cervical lymphadenopathy was present in only two cases (5.9%) of Ca maxilla and compressive optic neuropathy was present in the case of olfactory neuroblastoma. Bist et al found nasal mass in approximately 48.2% cases and facial swelling in 27.2% of the patients and cervical lymphadenopathy in 9.1% of the patients.
The second opinion was that the specimens represented an invasive, poorly differentiated NEC, probably a large-cell variant, with the differential diagnosis lying at a point somewhere between poorly differentiated large-cell NEC and high-grade olfactory neuroblastoma. The biopsy specimens contained part of an invasive, poorly differentiated malignant tumor that had infiltrated vascular turbinate tissue.
The differential diagnosis includes other small, round-cell tumors, such as lymphoma, rhabdomyosarcoma, olfactory neuroblastoma, melanoma, sinonasal undifferentiated carcinoma, and pituitary adenoma.
Olfactory neuroblastoma (esthesioneuroblastoma) is an uncommon malignant neuroectodermal nasal tumor that accounts for approximately 5% of all malignant neoplasms.