By delivering therapeutics to the upper nasal cavity, the POD nasal delivery platform takes advantage of the vascular rich olfactory region
for improved bioavailability and has the potential to target the brain via the olfactory and trigeminal nerves.
The percentage of Ag translocated to the OB via the olfactory region
of the nasal cavity at T0 for C20 and at T56 for C110 was calculated.
In two separate papers, Professors Amy Wagers and Lee Rubin, of Harvard's Department of Stem Cell and Regenerative Biology (HSCRB), report that injections of a protein known as GDF11, which is found in humans as well as mice, improved the exercise capability of mice equivalent in age to that of about a 70-year-old human, and also improved the function of the olfactory region
of the brains of the older mice - they could detect smell as younger mice do.
A bony horizontal plate called the lamina transversa sections off, and aids in airflow to the olfactory region
from the respiratory region.
Researchers in North Carolina have discovered that a specific gene associated with the olfactory region
in the brain not only serves as an "off switch" instructing neuronal stem cells, but the gene's lineage cells serve as "conductors" affecting the behavior of other stem cells in the olfactory bulb.
Nose-to-brain delivery is currently generating significant interest as direct delivery of active agents into the central nervous system via the olfactory region
offers some interesting therapeutic possibilities particularly in nerodegenerative diseases (Alzheimer's, Parkinson's, ischemia); yet, significant challenges remain to be overcome--in particular, the delivery of formulations to the absorptive site in man continues to be problematic and the most compelling current evidence for this route of delivery is predominantly from unvalidated animal models.
ViaNase is the only device proven to reach the olfactory region
in the brain, said Kurve's chief executive officer Marc Giroux.
They found that sniffs of EST activated the ordinary olfactory region
in straight women and gay men but fired up the hypothalamus, a region of the brain connected to sexual behavior, in straight men.
(2) Transport olfactory losses are caused by lesions that block the airflow to the olfactory region
of the nose.
In lizards and snakes, there is a single concha, which is located dorsally in the olfactory region
of the nasal cavity, and covered with sensory epithelium (Matthes 1934; Parsons 1970, 1971).
This area--which accounts for 80 percent of the human brain and is suspected of playing a role in everything from language processing to spatial tasks -- is thought to have evolved from and retained many of the features of the more primitive olfactory region
However, after inhalation of AND by men and EST by women, activation was observed in the amygdala, piriform cortex and anterior insular cortex (the olfactory regions
of the MOS route).