oligodendrocyte


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oligodendrocyte

[äl·i·gō′den·drə‚sīt]
(neuroscience)
Glial cell responsible for elaborating myelin in the central nervous system.
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But clemastines mechanism of action is poorly understood, Chan said, and pharmacologically speaking it is a dirty compound: in addition to its effects on histamine and muscarinic receptors, it interacts with many other types of receptors, and it affects many types of cells besides oligodendrocytes.
perfringens B strain, one of the subtypes that produces epsilon toxin, led to the death of oligodendrocytes and to loss of myelin, mimicking the changes seen in MS.
The researchers found that in a mouse model of ALS, caused by mutations in the SOD1 gene, oligodendrocytes degenerated before the mice displayed symptoms of the disease.
When oligodendrocytes are damaged or become dysfunctional in myelinating diseases, the insulating myelin coating that normally coats nerves is lost.
Moreover, the effect of PCB exposure on oligodendrocyte differentiation was similar to the effect of [T.
These RNAs are known to be located in oligodendrocyte processes [7], since these were highly enriched in myelin (3; Fig.
The discovery came fortuitously when Fancy and his team were studying how oligodendrocyte precursor cells (OPCs) differentiate into their mature form.
Way suggests, might improve oligodendrocyte survival during the inflammatory stresses of MS.
In the spinal cord, myelin is produced by oligodendrocytes, neuronal support cells formed through the differentiation of oligodendrocyte precursor cells.
This funding will be used to support the clinical development of GRNOPC1, Geron's cell therapy containing oligodendrocyte progenitor cells derived from human embryonic stem cells (hESCs), currently in a Phase 1 trial in patients with spinal cord injury.
Grantee Betty Soliven, MD (University of Chicago) teamed up with Jack Antel, MD (McGill University, Montreal) to examine the effects of fingolimod on oligodendrocytes (myelin-making cells), since S1P is involved in signaling by molecules in oligodendrocyte progenitors (immature oligodendrocytes).