Mixed glioma with molecular features of composite oligodendroglioma
and astrocytoma: a true "oligoastrocytoma"?
Two cases of astrocytomas were diagnosed as oligodendrogliomas
[Figure 4a and b].
A t(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma
. Cancer Res.
. In: Kleihues P, Cavenee WK, eds.
1p19q CODEL: A COMPARISON OF DIFFERENT TESTS FOR OLIGODENDROGLIOMA
Since 2012, histopathological markers such as MGMT, isocitrate dehydrogenase 1, and IP 19Q have become integral in the diagnosis and treatment of malignant brain tumors such as astrocytoma, oligodendroglioma
, and glioblastoma (Fig 1).
High grade oligodendrogliomas
showed that choline peak was 0.65 while in low grade it was 0.5 and NAA was 0.30 for low grade and 0.15 for high grade.
These markers are however of predictive value in oligodendroglioma
Their histologic characteristics include monomorphic clear cell glial morphology reminiscent of oligodendroglioma
, although they often express synaptophysin in addition to OLIG2 and S-100 [2, 3].
Moreover, based on the described histopathology, diverse glioblastoma variants are still emerging, such as glioblastoma with primitive neuroectodermal tumor-like component (GBM-PNET), GBM with oligodendroglioma
component (GBM-O), small cell astrocytoma, and granular cell astrocytoma .
 reported a case of a 14-month-old boy with a primary intraventricular oligodendroglioma
and obstructive hydrocephalus.
Nevertheless, rCBV obtained from region of interest- (ROI-) based method is inefficient for oligodendroglioma
grading, which demonstrates elevated rCBV regardless of tumor grade .