oligomycin


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oligomycin

[ə‚lig·ə′mīs·ən]
(microbiology)
Any of a group of antifungal antibiotics produced by an actinomycete resembling Streptomyces diastachromogenes ; the colorless, hexagonal crystals are soluble in many organic solvents.
References in periodicals archive ?
To study the sensitivity of the assay, several classical inhibitors of the mitochondrial energy-generating system were added to control fibroblasts: rotenone (for complex I), antimycin A (complex III), azide (complex IV), oligomycin (complex V), atractyloside [adenine nucleotide transporter (ANT)], [alpha]-hydroxycyanocinnamate (pyruvate carrier), and arsenite (PDHc and [alpha]-ketoglutarate dehydrogenase).
A peculiar finding was a slight loss of inhibition of oligomycin in the fibroblasts after 35 min; this was not seen in isolated muscle mitochondria.
Oligomycin hampers the oxidation of pyruvate and when added to the cell, it switches off the current.
Subsequent experiments with the F1F0-ATPase inhibitor oligomycin (5 [micro]g/ml) were performed to check whether a possible drop in the RCR derives from uncoupling or increased intramitochondrial metabolism of ATP.
This reduction may be explained by the effect of the inhibitory compounds of the plant extract on the existent chromophores groups in the respiratory chain or on the activity of FoF1-ATPase, as happens with oligomycin (Penefsky, 1985).