oligonucleotide


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Oligonucleotide

A deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) sequence composed of two or more covalently linked nucleotides. Oligonucleotides are classified as deoxyribooligonucleotides or ribooligonucleotides. Fragments containing up to 50 nucleotides are generally termed oligonucleotides, and longer fragments are called polynucleotides. See Deoxyribonucleic acid (DNA), Ribonucleic acid (RNA)

A deoxyribooligonucleotide consists of a 5-carbon sugar called deoxyribose joined covalently to phosphate at the 5 and 3 carbons of this sugar to form an alternating, unbranched polymer. A ribooligonucleotide consists of a similar repeating structure where the 5-carbon sugar is ribose. Chemically synthesized oligonucleotides of predetermined sequence have proven to be very useful for studying a large number of biochemical processes. In the 1960s, these compounds were used to decipher the genetic code. Later, chemically prepared deoxyoligonucleotides were joined to form genes for transfer RNAs. Gene synthesis from synthetic deoxyoligonucleotides is now routinely used to prepare genes and modified genes for proteins having potential clinical applications. Oligonucleotides have also been used to diagnose genetic disorders and bacterial or viral infections. See Gene, Genetic code, Genetic engineering, Nucleic acid

oligonucleotide

[‚äl·ə·gō′nü·klē·ə‚tīd]
(biochemistry)
A polynucleotide of low molecular weight, consisting of less than 20 nucleotide polymers.
References in periodicals archive ?
The two companies will work together to achieve their goal of providing a total solution for oligonucleotide drug companies across the globe.
Technological advancements are the key growth drivers for this market, as oligonucleotide synthesis is technology dependent.
This contract is for the supply, delivery and installation of an oligonucleotide synthesizer, designed to be integrated into the synthesis and purification of oligonucleotides platform of bioimaging Institute of the University of Bordeaux.
and Vorstand of Girindus AG, said, "This alliance with Marina is very important for Girindus as it clearly exemplifies our strategy to provide integrated services to our oligonucleotide customers.
Handbook of analysis of oligonucleotides and related products.
The Clarity OTX protocol uses a propriety mixture of chaotropes, detergents, and other dispersants to disrupt intermolecular interactions that are common for oligonucleotides in biological matrices.
The binding is sequence specific as shown by competition with unlabeled oligonucleotide of the same sequence.
The oligonucleotide containing the 3'-AzC group contained the 5' PDGF-BB aptamer sequence, a [C.
The oligonucleotide RpoB1UP is the same as the upstream rpoBF 1 but with a DNA uptake sequence (in lower case) that was added at the 5' end to permit DNA transformation (7).
Large-scale DNA and RNA oligonucleotide synthesis has now gained industry importance with proven therapeutic and diagnostic applications.
This alliance offers a straightforward solution for drug developers looking to minimize the challenges and risks associated with transitioning from a research-grade vendor to an oligonucleotide development service and manufacturing company.
The new reagent is designed to have amino modification of oligonucleotide.