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A deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) sequence composed of two or more covalently linked nucleotides. Oligonucleotides are classified as deoxyribooligonucleotides or ribooligonucleotides. Fragments containing up to 50 nucleotides are generally termed oligonucleotides, and longer fragments are called polynucleotides. See Deoxyribonucleic acid (DNA), Ribonucleic acid (RNA)

A deoxyribooligonucleotide consists of a 5-carbon sugar called deoxyribose joined covalently to phosphate at the 5 and 3 carbons of this sugar to form an alternating, unbranched polymer. A ribooligonucleotide consists of a similar repeating structure where the 5-carbon sugar is ribose. Chemically synthesized oligonucleotides of predetermined sequence have proven to be very useful for studying a large number of biochemical processes. In the 1960s, these compounds were used to decipher the genetic code. Later, chemically prepared deoxyoligonucleotides were joined to form genes for transfer RNAs. Gene synthesis from synthetic deoxyoligonucleotides is now routinely used to prepare genes and modified genes for proteins having potential clinical applications. Oligonucleotides have also been used to diagnose genetic disorders and bacterial or viral infections. See Gene, Genetic code, Genetic engineering, Nucleic acid

McGraw-Hill Concise Encyclopedia of Bioscience. © 2002 by The McGraw-Hill Companies, Inc.


A polynucleotide of low molecular weight, consisting of less than 20 nucleotide polymers.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Eurofins Genomics and Blue Heron have an inherent connection between their main product segments, oligonucleotides, sequencing and synthetic genes.
Avidity's platform seeks to combine the tissue selectivity of monoclonal antibodies and the precision of oligonucleotide-based therapeutics to potentially overcome barriers to the delivery of oligonucleotides and target genetic drivers of disease.
"Additionally, the opening of the new oligonucleotide API development center furthers our commitment to enhancing our service offerings and responsiveness to our customers' needs."
"Advances in Targeted Delivery of Anti-Sense Oligonucleotide Therapeutics to Pancreatic SS-Cells for Regenerative Approaches in Type 2 Diabetes," presented by Shalini Andersson, Senior Director and Head of New Modalities, AstraZeneca.
Allerson, Ph.D., vice president of chemistry at Stoke Therapeutics, presented preclinical data on the company's pipeline of novel antisense oligonucleotide therapeutics, which are designed to upregulate gene expression and treat an array of severe genetic diseases.
Isarna Therapeutics GmbH has signed a strategic manufacturing agreement with Sanofi under which Sanofi will manufacture clinical- and commercial-grade antisense oligonucleotide (ASO) compounds for Isarna, enabling Isarna to advance its promising next generation ASOs rapidly into clinical trials.
Tokyo, Feb 15, 2013 - (JCN) - Daiichi Sankyo will collaborate with a new company, Orphan Disease Treatment Institute, in the development of a treatment for Duchenne muscular dystrophy (DMD) with the active ingredient ENA oligonucleotide, a modified nucleic acid made using proprietary technology owned by Daiichi Sankyo.
Some oligonucleotide sequences can be manipulated easily enough, such as the letters within an abstract line of text.
Unlike existing antisense therapies that target RNA, an antigene drug is a triplex-forming oligonucleotide that recognizes and attaches directly to a specific DNA sequence.
While traditional methods require eight steps and can take two hours, the Clarity OTX extraction kits isolate oligonucleotide therapeutics and their metabolites in 15 minutes.
Oligonucleotide probes on microarrays that correspond to sequences throughout the entire genome have now been shown to produce quantitative hybridization responses under standardized conditions, allowing rapid and relatively inexpensive analysis of chromosomal copy number variation to be performed as a clinical test.
The binding is sequence specific as shown by competition with unlabeled oligonucleotide of the same sequence.