Severe congenital neutropenia often manifests with clinical manifestations of
omphalitis, abscess formation, otitis media, gingivitis and pneumonia within the first six months after birth (1,2,4).
Changing spectrum of neonatal
omphalitis. Pediatr Infect Dis J.
Poisson regression models and Cox survival regression models were used to compare neonatal mortality and umbilical stump infection (
omphalitis) across groups.
Umbilical discharge can be the result of acquired pathologies, such as pilonidal sinus of umbilicus (suggested as the most common cause in one study), acute
omphalitis [5], or congenital anomalies [6], but eccrine nevus and its variants have never been reported as a cause of umbilical discharge.
Bhutta, "Topical application of chlorhexidine to neonatal umbilical cords for prevention of
omphalitis and neonatal mortality in a rural district of Pakistan: a community-based, cluster-randomised trial," The Lancet, vol.
As in foals,
omphalitis often accompanies patent urachus and is believed to be involved in its pathogenesis.
Pneumonia ranked second (8.6%), followed by
omphalitis (4.3%), surgical site infection (2.4%) and impetigo (1.2%).
(24) Umbilical cord infections such as
omphalitis or tetanus neonatorum are more common in developing countries than high-income countries.
One was a 17-day-old infant who developed neonatal toxic
omphalitis and died despite aggressive treatment that included multiple debridements and broad-spectrum antibiotics.
(9) Extrapelvic infectious and inflammatory conditions were also noted: extensive skin infections with
omphalitis, (10) infected urachal remnant, (11) and hypersensitivity to chromate catgut sutures.
The most characteristic clinical finding is recurrent, severe bacterial infections beginning from birth, such as abscesses of perirectal skin or liver,
omphalitis, otitis media, and upper and lower respiratory tract infections, caused by common or uncommon bacterial agents [3,4].
Uncommon manifestations included desquamation 8.5%,
omphalitis 8% and birth trauma (7.7%).