oncocytoma


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oncocytoma

[‚äŋ·kō·sī′tō·mə]
(medicine)
A benign tumor composed principally of oncocytes; usually occurs in salivary glands.
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Nonneoplastic 11 Lymphoepithelial cyst 3 Inflammation 4 Epidermal inclusion cyst 1 Granuloma 1 Ectopic thyroid 1 Benign salivary gland 1 Benign 32 Monomorphic adenoma 1 neoplasm Pleomorphic adenoma 16 Warthin tumor 10 Granular cell tumor 2 Lipoma(tosis)/hibernoma 2 Oncocytoma 1 Malignant 14 Adenocarcinoma, NOS 4 neoplasm Mucoepidermoid carcinoma 4 Diffuse large B cell lymphoma 1 Carcinoma ex pleomorphic adenoma 1 Squamous cell carcinoma 2 Poorly differentiated carcinoma 1 Metastatic carcinoma 1 Abbreviation: NOS, not otherwise specified.
Pathologic features of the cases (n) (%) TNM stage T1a 76 (60.31) T1b 37 (29.36) T2a 13 (10.31) Pathology RCC Clear cell 83 (65.87) Papillary 11 (8.73) Chromophobe 6 (4.76) Oncocytoma 12 (9.52) Angiomyolipoma 14 (11.11) Fuhrman grade 1 36 (28.57) 2 80 (63.49) 3 10 (7.93) Positive 4 (3.17) surgical margin TNM: tumor-node-metastasis classification: RCC: Renal cell carcinoma
According to Hes O, Michal M the presence of GHG in a renal tumour may be of aid for excluding a diagnosis of chromophobe RCC or oncocytoma. They observed GHG in 49 of 64 cases of granular cell and mixed cell/ granular cell RCC.
reported that mtDNA mutations resulted in complex I deficiency in the mitochondrial respiratory chain in benign renal oncocytoma cells (19).
Among them, renal oncocytoma and chromophobe renal cell carcinoma (RCC) originate from intercalated cells in the collecting duct and share some morphologic, histologic, electron microscopy findings, and immunohistochemical characteristics (2, 3).
A total of nine patients were excluded from the study because they had non-RCC pathological type tumors (5 oncocytoma, 2 fat-poor angiomyolipoma and 2 upper urothelial cell carcinoma).
If pretreatment biopsy demonstrated oncocytoma and imaging post ablation shows treatment success, routine imaging beyond one year is not recommended (Level of evidence 5; Grade D).
Testosterone and cortisol-secreting adrenocortical oncocytoma: An unusual cause of hirsutism.
Four benign renal tumours were found, made up of oncocytoma (n=2), cystic nephroma (n=1) and angiomyolipoma (n=1).
Histological differential diagnoses include clear cell carcinoma, Warthin's tumor, mucoepidermoid carcinoma, and oncocytoma. (11)
Using a decision tree classifier, the identified miRNA signature showed a sensitivity of >95% for distinguishing normal from RCC and papillary RCC and showed 100% sensitivity for clear cell RCC and in distinguishing oncocytoma from chromophobe RCC subtype.