oncogene

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oncogene

any of several genes, first identified in viruses but present in all cells, that when abnormally activated can cause cancer

oncogene

[′äŋ·kō‚jēn]

(genetics)

A gene whose mutation can lead to cancer in experimental animals and humans.

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UCA1, upregulated in CRC, inhibited miR-204-5p activity, thus promoting the upregulation of miRNA targets CREB1, BCL2, and RAB22A (RAB22A, member RAS oncogene) and regulating cell proliferation and apoptosis [137].

Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer

As briefly mentioned in the Introduction, oncogene suppression under severe energy restriction most likely mirrors the fact that this condition is incompatible with sustained oncogenic signalling which drives commitment to clonal expansion and differentiation.

The Leukemic Stem Cell Niche: Adaptation to "Hypoxia" versus Oncogene Addiction

An oncogene panel is a targeted next-generation sequencing (NGS) approach, which can take a patient sample (from tumor tissue, not unaffected tissue) and simultaneously sequence all of these hundreds of understood genes on cell division control pathways.

Oncogene panels: a window into the individuality of cancers

Her-2 is an oncogene that plays an important role in human breast cancer.

Researchers Pinpoint Place Where Cancer Cells May Begin

oncogenes, effect cellular change through mutation of only one of the two gene copies.

The human oral cancer and molecular biology

RNA interference (RNAi) has emerged as a leading therapeutic strategy in oncogene therapy applications (Mello and Conti, 2004; Kim and Rossi, 2007).

Synthesis and characterization of GRP78 siRNAs for silencing gene expression in HepG2 liver carcinoma cells

pylori to the cells for cell proliferation, thymidine incorporation (at 8h), oncogene expression (at 24 h), ROS production (at 30 min), and NADPH oxidase activity (at 30 min).

[alpha]-lipoic acid inhibits Helicobacter pylori-induced oncogene expression and hyperproliferation by suppressing the activation of NADPH oxidase in gastric epithelial cells

Recent evidence has revealed that microRNAs (miRNAs) function as tumor suppressors and oncogenes, and therefore miRNAs might prove useful in the diagnosis and treatment of cancer.

MicroRNA involvement in human cancers

In cases where there is an amplification of the oncogene, an increase in the number of signals corresponding to HER2 is identified and an increase in relation to the signals of the gene and the centromeric signals of cromosome17 (14) (Fig.

Determinacion del estado de la amplificacion del Oncogen HER2 por hibridacion fluorecente in situ y concordancia con el metodo de inmunohistoquimica en muestras de mujeres Colombianas con Cancer de seno

Ngan, "Prevalence of RAS oncogene mutation in head and neck carcinomas," Journal of Otolaryngology, vol.

Prevalence of K-Ras codons 12 and 13 mutations in locally advanced head and neck squamous cell carcinoma and impact on clinical outcomes

Lastly, it brings together three major players involved in a myriad of normal and pathological processes: BCL6, an oncogene responsible for blood cell cancer; Sirt1, involved in aging, Alzheimer's disease, metabolism and diabetes; and the Notch pathway, crucial for many processes like brain and heart development or oncogenesis.

Blood cancer gene identified as key factor for differentiation of nerve cells

"The Irish Cancer Society funding has been, and continues to be, central to our research at UCC as we search for ways to prevent the oncogene from enhancing the ability of the cancerous tumour to survive."