"Think of cancer as a disease of the genome leading to abnormal activation of oncogenes
and inactivation of suppressor genes," he said.
Mutations in genes linked to cancer do not occur randomly but arise most often in certain regions of the oncogene
(14,21-23) We are currently investigating the quantitative differences in the expression of EphB4 with respect to tumor characteristics, induction of EGFRs, inactivation of tumor suppressor genes, and activation of oncogenes
. We are also interested in defining the role that EphB4 plays in the development and metastasis of HNSCC.
are activated by kinase domain mutations or by allosteric mutations.
According to the company, the overexpression of these HPV oncogenes
promotes the growth of malignant cells leading to the development of cervical cancer.
Second, they show that oncogenes
can regulate cell metabolism through alternative splicing, which may provide a new set of targets for oncogene-specific drug development.
Subsequent work revealed that let-7 regulates a number of other oncogenes
, including CCND2 (cyclin D2), CDK6 (cyclin-dependent kinase 6), CDC25 [cell division cycle 25 homolog C (S.
The authors showed that Myc regulates hundreds of genes that contain adenylate-uridylate-rich elements (AU-rich elements), which play an important role in RNA stability and are found in many messenger RNAs (mRNAs) that code for oncogenes
, nuclear transcription factors, and cytokines.
It explains why our war on cancer is off track--why examination for oncogenes
is of minimal value, why sensitivity test for chemotherapy agents is even more questionable, and why cancer work must now start from scratch looking at the chromosome and aneuploidy.
Zhong said he expects that suppressing other oncogenes
in other families of cells would have the same effect, which could have critical significance for stem cell therapy.
The volume is divided into five main sections: physiological resistance; biological resistance; biochemical resistance; hormones, growth factors, and oncogenes
; and clinical aspects.
2) Can oncogenes
and their associated mutations affect asymmetric versus symmetric divisions in stem cells?