(1,17) This finding highlights the importance of the cell of origin in the
oncogenesis of different entities with recurrent gene fusions, (4) a concept perhaps best illustrated by the recurrent ETV6-NTRK3 gene fusions across biologically distinct tumors of epithelial, mesenchymal, and hematopoietic differentiation (secretory carcinoma, infantile fibrosarcoma, and acute myeloid leukemia, respectively).
NSD1 mutation has recently been linked to the blocking of cellular differentiation and the promotion of
oncogenesis in this type of tumor.
Debnath, "Modeling morphogenesis and
oncogenesis in three-dimensional breast epithelial cultures," Annu Rev Pathol, vol.
Failed regulation of both types of miRNAs promotes
oncogenesis, proliferation and invasion of cancer cells, and the epithelial-mesenchymal transition (EMT).
Despite their mysterious origin, intergenically spliced chimeric RNAs are found across tissue types and have proven importance in normal cell states [2, 3, 5, 8] as well as demonstrated roles in both
oncogenesis and cell differentiation.
The incidence of AIN with nonrenal cancer [11,12] indicates that the presence of underlying renal
oncogenesis is not associated with AIN.
MYB driver mutations associated with
oncogenesis have been confirmed in several types of malignancies including leukemias and adenoid cystic carcinomas [21].
For gliomas, which represent 75% of all malignant brain tumors, N-acetylaspartate (NAA) and 2-hydroxyglutarate (2HG) are markers of
oncogenesis, and their MS measurement in brain tissue has the potential to improve glioma diagnosis.
There is data to suggest that poor dental health results in alteration in the oral flora and this may well play an etiological role in
oncogenesis through an inflammatory process.
Being the first disease to correlate cancer and viral infection, EV serves as the cornerstone of the understanding of viral
oncogenesis. We report three cases of EV, of which one patient subsequently developed Bowen's disease.