D, Lymphatic tumor emboli (arrows) are strongly positive for HER2 oncoprotein
expression (hematoxylin-eosin, original magnifications X100 [A] and X200 [B]; original magnification X200 [C and D]).
of high risk HPV-16 upregulate MT1-MMP, MMP-2 and MMP-9 and promote the migration of cervical cancer cells.
Trivedi et al., "MUC1 oncoprotein
activates the IkB kinase complex and constitutive NF-[kappa]B signalling," Nature Cell Biology, vol.
Control of microtubule dynamics by oncoprotein
18: dissection of the regulatory role of multisite phosphorylation during mitosis.
(2003) Helicobacter pylori CagA--a potential bacterial oncoprotein
that functionally mimics the mammalian Gab family of adaptor proteins.
Our data show that thyroid tumors carrying BRAFV600E mutations are exquisitely dependent on the oncoprotein
for viability and that genetic or pharmacological inhibition of its expression or activity is associated with tumor regression and restoration of radioactive iodine uptake in vivo in mice.
Chen, "Structures of a human papillomavirus (HPV) E6 polypeptide bound to MAGUK proteins: mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein
," Journal of Virology, vol.
The integration of HPV16 DNA promotes a constitutive high expression of E6 oncoproteins
and results in the extensive proliferation of the infected epithelial cells.
The viral E6 and E7 oncoproteins
are necessary for malignant conversion of cells (Lipari et al., 2001).
(10) On his initial colon biopsy, our patient had positive staining for the EBV oncoprotein
, LMP1, which is frequently observed in HL.
The "triple negative" invasive breast carcinoma are tumors negative for Estrogen receptor (ER), Progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) oncoprotein
Papillomavirus E5: the smallest oncoprotein
with many functions.