oncogene

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oncogene

any of several genes, first identified in viruses but present in all cells, that when abnormally activated can cause cancer
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005

oncogene

[′äŋ·kō‚jēn]
(genetics)
A gene whose mutation can lead to cancer in experimental animals and humans.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
D, Lymphatic tumor emboli (arrows) are strongly positive for HER2 oncoprotein expression (hematoxylin-eosin, original magnifications X100 [A] and X200 [B]; original magnification X200 [C and D]).
E6/E7 oncoproteins of high risk HPV-16 upregulate MT1-MMP, MMP-2 and MMP-9 and promote the migration of cervical cancer cells.
Trivedi et al., "MUC1 oncoprotein activates the IkB kinase complex and constitutive NF-[kappa]B signalling," Nature Cell Biology, vol.
Control of microtubule dynamics by oncoprotein 18: dissection of the regulatory role of multisite phosphorylation during mitosis.
(2003) Helicobacter pylori CagA--a potential bacterial oncoprotein that functionally mimics the mammalian Gab family of adaptor proteins.
Our data show that thyroid tumors carrying BRAFV600E mutations are exquisitely dependent on the oncoprotein for viability and that genetic or pharmacological inhibition of its expression or activity is associated with tumor regression and restoration of radioactive iodine uptake in vivo in mice.
Chen, "Structures of a human papillomavirus (HPV) E6 polypeptide bound to MAGUK proteins: mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein," Journal of Virology, vol.
The integration of HPV16 DNA promotes a constitutive high expression of E6 oncoproteins and results in the extensive proliferation of the infected epithelial cells.
The viral E6 and E7 oncoproteins are necessary for malignant conversion of cells (Lipari et al., 2001).
(10) On his initial colon biopsy, our patient had positive staining for the EBV oncoprotein, LMP1, which is frequently observed in HL.
The "triple negative" invasive breast carcinoma are tumors negative for Estrogen receptor (ER), Progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) oncoprotein analysis.
Papillomavirus E5: the smallest oncoprotein with many functions.