ookinete


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ookinete

[‚ō·ə′kī‚nēt]
(invertebrate zoology)
The elongated, mobile zygote of certain Sporozoa, as that of the malaria parasite.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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Sequence variation of ookinete surface proteins pvs25 and pvs28 of Plasmodium vivax isolates from southern Mexico and their association to local anophelines infectivity.
Immunological defense plays a key role when ookinete traverses the midgut and sporozoites migrate to the salivary glands [11].
Phylogenetic Gene ID classification Trophozoite Schizont Merozoite PF3D7_0204700 Clade 2 + + + PF3D7_0919500 Clade 4 nd nd nd Blood stage Gene ID Gametocyte I Gametocyte II Gametocyte III PF3D7_0204700 + + nd PF3D7_0919500 nd nd nd Mosquito/sexual stage Gene ID Gametocyte IV Gametocyte V Ookinete Sporozoite PF3D7_0204700 nd + nd + PF3D7_0919500 nd nd nd + Phylogenetic classification (see Figure 1); +: protein expression is detected; nd: not detected.
Plasmodium enolase plays a crucial role during ookinete invasion of mosquito midgut, an essential step in Plasmodium life cycle in mosquito.
During this phase, it is possible to interrupt the fertilization process and ookinete invasion to the mosquito's intestinal cells, preventing development of the parasite within the mosquito and, hence, its transmission to other susceptible individuals (14).
The Imperatoxin I completely inhibited both fecundation and ookinete formation within in vitro micromolar concentrations [53].
Anti-vector transmission-blocking vaccines inhibit parasite development by preventing ookinete Interaction with mosquito midgut ligands.
More significantly, this study discovered the Imd pathway signal transducing factors and effectors that will mediate a successful reduction of parasite infection at their early ookinete stage, as well as in the later oocyst stage when the levels of infection were similar to those found in nature.
Cryofracture electron microscopy of the ookinete pellicle of Plasmodium gallinaceum reveals the existence of novel pores in the alveolar membranes.
Plasmodium gallinaceum: a refractory mechanism of ookinete killing in the mosquito, Anopheles gambiae.
Gametes in the body of the mosquito combine to create a zygote and then an ookinete that penetrates the intestinal epithelium of the mosquito, forming an oocyte [55, 56].
AZT might interfere with transmission by exoerythrocytic inhibition of parasite liver stages in humans and mice (3) and by interference with ookinete and sporozoite production in mosquitoes (4).