Even though the natural role of opsonisation
is directed to the body protection from xenogeneic nanosystems, this process promotes the removal of circulating drug nanocarriers.
Finally, the remotion of immune complex from parasite surface seems tobe important to evade the complement and phagocytosis by opsonisation
. Shedding was shown in Leishmania and in T cruzi .
Soon after, C3 and C5 become cleaved into smaller proteins that mobilizeto form the membrane attach complex and are directly responsible for the opsonisation
and death of foreign microorganisms.
Similarly, AP also augmented by opsonisation
of bacteria with IgG and complement fixation (Asbury, 1984).
Activation of the complement system by antigens (classic way) or by surface pathogens finally leads to taxis of inflammatory cells, opsonisation
of pathogens and destroy of pathogens.
This can be reduced to a certain extent with the advent of stealth liposomes where the liposomes are coated with materials like polyoxyethylene (4) which prevents opsonisation
of the liposome and their uptake by macrophages (5).
(10-12) Immunoglobulins are crucial components of humoral immunity, having pathogen neutralisation and opsonisation
functions that occur during primary and/or secondary antibody responses.
There are many disorders in the immune system of [beta]-thalassemia patients including cell mediated immunity (7) and both functional, quantitative and other components of the immunity (8), involving immunoglobulins increasing, complement system with lower activity and decline in granulocyte phagocytosis and the opsonisation
IgM is 100 to 400 times greater than immunoglobulin G (IgG), and the opsonisation
of bacteria by IgM is also approximately 1,000 times greater than IgG.2 Despite Cochrane not recommending it, pentaglobin is still used as a supportive agent in the treatment of newborns with nosocomial sepsis in many newborn units.
Furthermore, its structural features suggest a possible role in opsonisation
, activating a complement through the lectin complement pathway .
Second, during the effectuation phase, opsonisation
of PEGylated liposomes by anti-PEG IgM primes them for elimination by liver macrophages .