opsonize


Also found in: Dictionary, Thesaurus, Medical, Wikipedia.

opsonize

[′äp·sə‚nīz]
(immunology)
To render microorganisms susceptible to phagocytosis.
References in periodicals archive ?
Opsonophagocytosis assay: Convalescent serum samples from pharyngitis cases were compared for their ability to opsonize GAS (7).
The B-face of CRP recognizes phosphocholine epitope of bacteria to opsonize them.
Recent studies indicate that MBL could opsonize HIV but does not induce neutralization of virus within the physiological concentration range (62).
Plausible mechanisms of actions propose (1) synthetic fragment of A[beta] are designed at crossing the blood-brain barrier via their epitope to opsonize A[beta] whereas their Fc fragment is recognized by receptor-mediated phagocytosis by microglia, (2) administrating into the vasculature system antibody targeting A[beta] whose complex will be cleared from blood circulation preventing A[beta] to enter into the brain to form new plaques or modified antibody that altered the blood-brain barrier permeability used to drain out A[beta] from the brain into the blood circulation to enhance clearance of soluble A[beta] and (3) administration of antibody inhibitors preventing amyloid accumulate in plaque [180].
Fetuin-A acts as a ubiquitous cofactor, usually required to opsonize cationic macrophage deactivating molecules (10).
Complement system uses three independent pathways to distinguish bacteria from host cells and then can rapidly recognize and opsonize bacteria or kill gram-negative bacteria directly by formation of the membrane attack complex [10].
Moreover, a bacterial ganglioside-like epitope stimulates B cells to induce antibodies that opsonize cross-reactive axolemmal antigens, fix complement and target macrophages to invade the periaxonal space, block conduction, or cause axonal degeneration.