acidemia

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Related to organic acidemia: aciduria

acidemia

[‚as·ə′dēm·ē·ə]
(medicine)
A condition in which the pH of the blood falls below normal.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The short-chain acylcarnitine C3 is an extremely important diagnostic marker for certain organic acidemias. It is detected at m/z 274 by use of a Pre 85 scan function.
In addition, based on our experience, it may be easier to diagnose organic acidemias and short-chain acylcarnitine disorders in blood rather than in bile because, relatively speaking, these metabolites are apparently excreted at lower concentrations in bile than in blood (based on the data presented here).
Their group focuses on Michael's specific organic acidemia, glutaric acidemia type 1, a disorder that has a high incidence rate in the Amish community.
Organic acidemias caused by mitochondrial enzyme defects in the catabolism of branched-chain amino acids and fatty acid oxidation defects constitute a group of >20 disorders in which acyl-CoA esters accumulate in the mitochondria.
This study will help us devise protocols for sample collection and workup of suspected IMDs that is beneficial for prompt interpretation and diagnosis of cases especially those demanding detection or exclusion thereof of organic acidemias.
Clinical features and management of organic acidemias in Japan.
Group of organic acidemias, like methylmalonic acidemia, propionic acidemia and isovaleric acidemia.
Organic acidemias are disorders of intermediary metabolism that lead to the accumulation of toxic compounds that derange multiple intracellular biochemical pathways, including glucose catabolism (glycolysis), glucose synthesis (gluconeogenesis), amino acid and ammonia metabolism, purine and pyrimidine metabolism, and fat metabolism.
The diseases detected include amino-acidemias, fatty acid oxidation disorders, and organic acidemias.
Supplemental newborn screening using acylcarnitine ester profiling has greatly expanded the scope of detection of newborns with a wide range of fatty acid oxidation disorders and organic acidemias. Each metabolite, or group of metabolites, measured by tandem mass spectrometry in the newborn blood spot carries the potential to identify infants at risk for metabolic disease.
A GC/MS/MS screening method for multiple organic acidemias from urine specimens.