Even though it's organic arsenic
being fed to these chickens, [they contain] a lot more inorganic arsenic at the end of the day," says John F.
Biopharmaceutical company ZIOPHARM Oncology Inc (Nasdaq:ZIOP) reported on Monday that it has been granted a patent in Japan covering pharmaceutical compositions, including oral formulations, of various organic arsenic
compounds, including darinaparsin (Zinapar or ZIO-101).
Almost nothing is known regarding health effects of organic arsenic
compounds in humans," says the Agency for Toxic Substances and Disease Registry.
A second organic arsenic
from that broad licensing arrangement, ZIO-102, is expected to undergo further preclinical study this year as ZIO-101 progresses through phase I study in both hematologic and solid tumor cancers.
Due to inorganic arsenic trioxide's severe cardiotoxicity and neurotoxicity profile, darinaparsin, an organic arsenic
, was thought to be a far better treatment candidate and these studies encourage additional preclinical and clinical study, as a single agent and in combination.
Occurrence and stability of inorganic and organic arsenic
species in wines, rice wines, and beers from central European market.
In any case, total urinary arsenic reflects the number of arsenic ions generated from all arsenic species in the urine, including inorganic arsenic (AsIII, AsV), the tri- and pentavalent methylated metabolites of inorganic arsenic [monomethylarsonite (MMAIII), dimethylarsinite (DMAIII), monomethylarsonate (MMAV), dimethylarsinate (DMAV)] and the less toxic organic arsenic
compounds commonly associated with dietary exposures, particularly in seafood (mainly arsenobetaine, arsenosugars, and arsenolipids) (Caldwell et al.
Little is known about the relationship of organic arsenic
compounds and humans (ATSDR, 2007).
So people who eat seafood are going to be exposed to very high levels of arsenic, but in this case it's this type of organic arsenic
that is actually nontoxic, so when we do research we need to always be very careful about exposure assessment, and we need to distinguish between inorganic and organic arsenic
At the time roxarsone was approved, scientists believed its organic arsenic
base would be excreted unchanged.
Similarly, ZIOPHARM's darinaparsin, ZIOPHARM's anti-mitochondrial organic arsenic
compound, is expected to commence a pivotal program in Q4'11 in refractory peripheral T-cell lymphoma (PTCL).
nontoxic organic arsenic
from dietary sources) from the total.