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Organizing pneumonia with a positive result for anti-CCP antibodies as the first clinical presentation of rheumatoid arthritis.
Originally used by Katzenstein to encompass diffuse alveolar damage (DAD) and the entity previously known as bronchiolitis obliterans with organizing pneumonia, now known as organizing pneumonia (OP), the term was meant to reflect the relatively acute onset of both entities as well as the temporal uniformity of both processes.
It provides the appropriate sampling particularly in the diagnosis of tuberculosis, organizing pneumonia (OP), and respiratory bronchiolitis in which the involvement of the disease is apparent in the center of or around the bronchioles and in the diagnosis of some diseases such as lymphangitis carcinomatosa and sarcoidosis which have involvement throughout the lymphatic distribution (2).
Several immunosuppressive adverse effects were linked to the treatment, including Kaposi's sarcoma, organizing pneumonia, tuberculous lymphadenitis, squamous cell carcinoma, melanoma, and seven cases of progressive multifocal leukoencephalopathy.
Cryptogenic organizing pneumonia is a rare lung pathology described for the first time by Davison in 1983 and 2 years later by Epler under the name idiopathic bronchiolitis obliterans organizing pneumonia (BOOP) [1-3].
Idiopathic interstitial pneumonias comprise the following disease entities, listed in decreasing order of frequency: Idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP), cryptogenic organizing pneumonia (COP), acute interstitial pneumonia (AIP), respiratory bronchiolitis-associated ILD (RB-ILD), desquamative interstitial pneumonia (DIP) and lymphoid interstitial pneumonia (LIP) (6)
Definitive diagnosis of cryptogenic organizing pneumonia is based on a suggestive clinical radiological presentation, the demonstration of the characteristic pathological pattern at lung histopathology, and exclusion of possible causes.
In addition, secondary changes including small foci of organizing pneumonia may be observed (2).
Organizing pneumonia with or without bronchiolitis obliterans (Bronchiolitis obliterans organizing pneumonia--BOOP) accounts for about 25% of cases.
The use of steroids in a single case of vivax malaria complicated with bronchilotis obliterans organizing pneumonia (BOOP) is reported in literature (8).
The major IIPs include idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP), acute interstitial pneumonia (AIP), and bronchiolitis obliterans organizing pneumonia (BOOP).

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