Effects of organoselenium compound
2-(5-selenocyanato-pentyl)-benzo [de] isoquinoline 1, 3-dione on cisplatin induced nephrotoxicity and genotoxicity: An investigation of the influence of the compound on oxidative stress and antioxidant enzyme system.
in cancer chemoprevention.
Differential apoptotic response of human cancer cells to organoselenium compounds
. Cancer Chemother Pharmacol.
Two organoselenium compounds, selenomethionine (SeM) and Se-methylselenocysteine (SeMSC), known to have anticancer properties (Zeng 2009; Sanmartin et al.
Differential effects of naturally occurring and synthetic organoselenium compounds on biomarkers in androgen responsive and androgen independent human prostate carcinoma cells.
find applications due to their biological activity and useful synthetic properties (see [1, 2] and references cited therein).
Consequently, [(PhTe).sub.2] can be used as a tool to study pharmacological agents that could counteract the toxic effect of ditelluride on brain phosphorylating/ dephosphorylating system, for instance, organoselenium compounds with neuroprotective effects [17, 92, 93].
Au et al., "Organotellurium and organoselenium compounds attenuate Mn-induced toxicity in Caenorhabditis elegans by preventing oxidative stress," Free Radical Biology and Medicine, vol.
Other dietary components appear to have similar action, including iosthiocyanates, which are found in sulfur and cruciferous vegetables, such as cabbage, kale, broccoli, and watercress; organoselenium compounds
found in garlic; biotin-rich foods such as chard and egg yolk, and alpha lipoic-acid-rich foods, such as green leafy vegetables.
Among the topics are the stem cell paradigm and its application to prostate cancer, interactions between the androgen receptor and other signaling pathways implicated in prostate cancer growth and development, organoselenium compounds
as a prospect for therapy, molecular genetic alterations in the prostate cancer microenvironment, implication of lysophosphatidic acid signaling and receptor-mediated mechanisms contributing to the development of prostate carcinoma, redox state and prostate cancer behavior, and how piezoelectric interaction with prostatic crystalloids may explain the relationship between environmental electromagnetic fields and prostate cancer.
In general, organoselenium compounds are more reactive than their sulfur counterparts: the C-Se bond (234 KJ/mol) is weaker than the C-S bond (272 KJ/mol).
They then used their method in a study of several organoselenium compounds, including selenonium compounds, and reported various degrees of metabolism to TMSe by the different compounds.