Differential apoptotic response of human cancer cells to organoselenium compounds
Two organoselenium compounds, selenomethionine (SeM) and Se-methylselenocysteine (SeMSC), known to have anticancer properties (Zeng 2009; Sanmartin et al.
Differential effects of naturally occurring and synthetic organoselenium compounds on biomarkers in androgen responsive and androgen independent human prostate carcinoma cells.
Other dietary components appear to have similar action, including iosthiocyanates, which are found in sulfur and cruciferous vegetables, such as cabbage, kale, broccoli, and watercress; organoselenium compounds
found in garlic; biotin-rich foods such as chard and egg yolk, and alpha lipoic-acid-rich foods, such as green leafy vegetables.
Among the topics are the stem cell paradigm and its application to prostate cancer, interactions between the androgen receptor and other signaling pathways implicated in prostate cancer growth and development, organoselenium compounds
as a prospect for therapy, molecular genetic alterations in the prostate cancer microenvironment, implication of lysophosphatidic acid signaling and receptor-mediated mechanisms contributing to the development of prostate carcinoma, redox state and prostate cancer behavior, and how piezoelectric interaction with prostatic crystalloids may explain the relationship between environmental electromagnetic fields and prostate cancer.
In general, organoselenium compounds
are more reactive than their sulfur counterparts: the C-Se bond (234 KJ/mol) is weaker than the C-S bond (272 KJ/mol).
AMEX: ALT) has entered into a worldwide exclusive license under which OXIS has granted Alteon exclusive rights to a family of orally bioavailable organoselenium compounds
that have demonstrated potent anti-oxidant and anti-inflammatory properties in clinical and preclinical studies.