Orotic Acid

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orotic acid

[ə′räd·ik ′as·əd]
C4H4O4N2 A crystalline acid which is a growth factor for certain bacteria and is also a pyrimidine precursor.

Orotic Acid


(also 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidine-carboxylic acid or uracil-6-carboxylic acid), colorless crystals that are poorly soluble in water and organic solvents; melting point, 323°-345°C (with decomposition). Orotic acid was first extracted from cow’s milk in 1905 and later discovered in the milk of other animals and humans. Concentrated mainly in yeasts and in the liver, it is synthesized from aspartic acid and takes part in the biosynthesis of pyrimidine nucleotides, including uridine-5’-monophosphate and cytidine monophosphates. It also stimulates growth in plants and animals. The potassium salt of orotic acid is used in medicine to treat disorders in protein metabolism.

References in periodicals archive ?
An elevated serum ammonia level, particularly with normal liver enzymes and the absence of relevant medications, should suggest an inborn error of metabolism and prompt treatment of the hyperammonemic state followed by measurement of plasma amino acid and urine orotic acid levels.
Late-season skim milk led to a greater increase in FEUA, compared with either ultrafiltered skim milk or early-season skim milk, suggesting that the acute urate-lowering effect of orotic acid may explain these effects.
We purchased the following compounds from Sigma: adenine, adenosine, 2-deoxyadenosine, 2-deoxyguanosine, inosine, 2-deoxyinosine, xanthine, hypoxanthine, orotic acid, uric acid, thymine, uracil, dihydrothymine, dihydrouracil, N-carbamyl-[beta]-aminoisobutyric acid, N-carbamyl-[beta]-alanine, thymidine, uridine, pseudouracil, 5-hydroxymethyluracil, and 2-deoxyuridine.
This method for the quantification of glutamine in plasma supplements the measurements of plasma ammonia and urine orotic acid commonly used to monitor patients with urea cycle defects.