orphan

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Related to orphan products: Orphan Drug Act

orphan:

see adoptionadoption,
act by which the legal relation of parent and child is created. Adoption was recognized by Roman law but not by common law. Statutes first introduced adoption into U.S. law in the mid-19th cent.
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; foundling hospitalfoundling hospital,
institution for receiving and caring for abandoned children. In Athens and in Rome until the 4th cent., unwanted children were exposed, or left to die, in appointed places. The first modern foundling hospital was established by the archpriest of Milan in 787.
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; guardian and wardguardian and ward,
in law. A guardian is someone who by appointment or by relationship has the care of a person or that person's property, or both. The protected individual, known as the ward, is considered legally incapable of acting for himself or herself; examples are a child
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.

What does it mean when you dream about an orphan?

The orphan is a symbol of an unwanted, unloved child, one who is needy, misunderstood, and abused by strict, un-nurturing people who exert merciless control and authority. This symbol may represent childhood memories and fears of being abandoned. The dreamer may be resisting inner needs to be childlike, or be emotionally cold and withdrawn from others who are close to the dreamer.

Orphan

See also Abandonment.
Adverse, Anthony
finally, at middle age, discovers origins. [Am. Lit.: Anthony Adverse]
Carey, Philip
brought up by stingy uncle and kindly aunt. [Br. Lit.: Of Human Bondage, Magill I, 670–672]
Cass, Eppie
child found and brought up by Silas Marner. [Br. Lit.: Eliot Silas Marner in Benét, 930]
Clickett
the “orfling” from St. Luke’s workhouse; Mrs. Micawber’s maid-of-all-work. [Br. Lit.: David Copperfield]
Cosette
waif indentured to the cruel Thenardiers; saved by the honorable Valjean. [Fr. Lit.: Les Miserables]
Dondi
Italian war baby taken in by Americans. [Comics: Horn, 217]
Finn, Huckleberry
his mother dead; his father dies toward end of novel. [Am. Lit.: Huckleberry Finn]
Little Orphan Annie
feisty waif succored by paternal Daddy Warbucks. [Comics: Horn, 459]
Luck, Thomas
infant adopted by miners when his prostitute mother dies. [Am. Lit.: Bret Harte “The Luck of Roaring Camp” in Magill III, 597]
Pip
Philip Pirrip, orphaned as an infant. [Br. Lit.: Great Expectations]
Twist, Oliver
foundling reared in school of hard knocks. [Br. Lit.: Oliver Twist]
References in periodicals archive ?
Funds for research through Orphan Products Grants Programs benefit from a 50% deduction tax credit for clinical trial expenses (9) and a market exclusivity of 7 years.
Since its creation in 1983, the Orphan Products Clinical Trials Grants Program has provided more than $370 million to fund more than 590 new clinical studies and supported the marketing approval of more than 55 products.
Cote rejoin the FDA as the new head of the Orphan Products Development office," said Janet Woodcock, M.D.
1379 will fortify the ORD by making it a permanent office at NIH; giving it statutory authority which will allow it to form its own research agenda; doubling its budget to $4 million in Fiscal Year 2002 and "such sums as may be necessary" for each subsequent fiscal year; authorizing new funds for Rare Disease Research Centers of Excellence in the amount of $20 million; and doubling the funding of the Orphan Product Research Grant Program at the FDA-which receives 100 grant applications yearly-to $25 million in FY 2002.
- Israeli clinical-stage company Ayala Pharmaceuticals has been granted Orphan Drug Designation from the US Food and Drug Administration's Office of Orphan Products Development for AL101, a potent and selective inhibitor of gamma secretase-mediated Notch signalling, for the treatment of ACC, the company said.
Fibrocell Science announced that the FDA office of orphan products development, or OOPD has awarded a $1.4M clinical trial research grant for Fibrocell's continued clinical development of FCX-007, the company's gene therapy candidate for the treatment of recessive dystrophic epidermolysis bullosa, or RDEB, a rare skin blistering disease with high mortality.
Biopharmaceutical company Stealth BioTherapeutics revealed on Monday the receipt of the US Food and Drug Administration (FDA) Office of Orphan Products Development's orphan drug designation for investigational drug candidate, elamipretide, for the treatment of Leber's hereditary optic neuropathy (LHON).
This will be the first time the FDA will provide funding through its Orphan Products Grants to conduct these types of studies for rare diseases.
Orphan products are developed to treat rare diseases or conditions that affect fewer than 200,000 people in the U.S.
The French Ministry of Research is backing orphan products research through national programmes covering genome research with funding of over Euro 30 million per year.German legislation provides for the rapid authorisation of medicines of great therapeutic value, with simplified procedures where the treatment is in the public interest, and the federal Government's new health research programme include creation of a national network for groups of rare diseases.
Techniclone Corporation (Nasdaq:TCLN), Tustin, Calif., a developer of leading-edge unique therapeutics for the advanced treatment of cancer, has announced that the Office of Orphan Products Development of the FDA has determined that Oncolym qualifies for orphan designation for the treatment of intermediate and high-grade B-Cell Non-Hodgkin's Lymphoma.
According to a report recently released by the Pharmaceutical Manufacturers Association, in cooperation with the Food and Drug Administration's Office of Orphan Products Development and the National Organization for Rare Disorders, 133 orphan drugs that combat 96 rare diseases are currently being developed.