The histopathological variants are parakeratinized, orthokeratinized and combination of the two.
Three histopathological types of lining of odontogenic keratocysts were identified as parakeratinized, orthokeratinized and the combination of both of the variants.
Histopathological sections revealed a cystic cavity lined by orthokeratinized
,stratified squamous epithelium.
Although unnecessary for diagnosis, there is a high Ki-67 and p53 expression in the neoplastic cells, ft is important to separate KCOTs from dentigerous cysts, orthokeratinized
odontogenic cysts, and periapical cysts, as these other entities do not have the same potential for recurrence or syndrome association.
An incisional biopsy revealed few areas of hyperplastic, orthokeratinized
and parakeratinised stratified squamous epithelium and connective tissue exhibiting mixture of dense and loose fibrous component Inflammatory cell infiltrate with Polymorpholeukocytes (PMLs) and dilated blood capillaries were also evident
Tissue from buccal mucosa showed stratified squamous orthokeratinized
epithelium with loss of rete pegs.
Orthokeratinized odontogenic cyst (OOC) is a relatively uncommon developmental cyst comprising about 10% of cases that had been previously coded as odontogenic keratocysts (OKCs).
The orthokeratinized surface layers were relatively thick, and onion-skin-like.
Histologically, the RCP is composed of vascular connective tissue with or without the presence of stellate-shaped or multinucleated fibroblasts and is surfaced by orthokeratinized
or parakeratinized stratified squamous epithelium.
6 Orthokeratinized odontogenic cyst does not show pallisading of basal cells and is histologically different from parakeratinized OKC showing less aggressive behavior and destruction.
This much varied recurrence is due to varying periods of follow up, inclusion of orthokeratinized odontogenic cyst or not, and also on treatment modality adopted.
Odontogenic Cyst (OOC) was first described by Schultz in 1927 and in 1945 Philipsen considered it to be a type of odontogenic keratocyst.