In summary, the current report demonstrated that calcium and silymarin alone or in combination with each other have a preventative effect against osteoporosis and this treatment may dictate its effect via bone resorption processes, and in each of the treatments, silymarin or calcium has its own independent way to compromise osteoclastic
bone resorption activity.
Bone loss is accelerated due to uncontrolled osteoclastic
bone resorption occurs via the vacuolar H+ATPase which pumps protons out into the lacuna.
Although the cellular origin of primary giant-cell tumor of the salivary gland remains uncertain, ultrastructural findings and immunohistochemical staining for CD68, lysozyme, and other histiocytic markers suggest that the giant cells are of osteoclastic
or histiocytic lineage.
Once lead is incorporated into the crystalized architecture of bone, not only does it become a dormant structural component of the osseous matrix until osteoclastic
activity can release it into the circulation (Klein and Wiren 1993; Rabinowitz 1991) but it also may be affected by bone resorption (Tsaih et al.
Bone marrow biopsy showed marked plasmacytosis with 50% to 70% infiltration and osteoclastic
invasion of bone.
Further chemical investigation led to the isolation of 17 flavonoids, most of which showed significantly stimulatory effect on osteoblastic proliferation, ALP activity and mineralized nodes formation as well as inhibitory effect on osteoclastic
TRAP activity in osteoblastic and osteoclastic
For instance, following spinal cord injury, sympathetic nervous system affects the circulation in bone and causes transformation of mesenchymal cells into osteoclastic
Bone turnover improved selectively in women >70 years old, as assessed by the dualenergy x-ray absorptiometry (DEXA) technique and the decrease of osteoclastic
Several recent clinical studies assessing soluble bone turnover markers in patients taking anti-TNF-alpha have shown a significant decrease in bone resorption associated with a decrease in osteoclastic
which act upon osteoblasts and osteoclasts to cause inflammation and osteoclastic
bone resorption [8, 15].
This time of activated bone turnover as a result of osteoclastic
activity is a very high-risk period for bone metastases in women who have breast cancer, he said.