well defined osteolytic
lesion in the body of the sternum (Figure 4).
On imaging, multiple myeloma is hallmarked by focal or diffuse marrow infiltration and well-circumscribed osteolytic
The 29 patients included 22 subjects with osteolytic
metastases (renal cell cancer [n=5], breast cancer, [n=5], follicular thyroid cancer [n=4], neuroendocrine cancer, [n=2], papillary thyroid cancer [n=1], pancreatic cancer, [n=1], cervical cancer [n=1], sarcomatoid carcinoma [n=1], colorectal cancer [n=1] and carcinoma of unknown primary [n=1]) and 7 subjects with multiple myeloma (n=7) (Table 1).
Hemangioma involving the proximal ulna is extremely rare; however, a radiologist should be aware and consider this entity in the differential diagnosis of a medullary based, expansile, osteolytic
lesion with soap-bubble appearance affecting a long tubular bone, particularly on CT and MRI.
Tibia x-rays demonstrated exuberant cortical intramedullary bone formation, with the disappearance of the scalloped osteolytic
lesions on the inner wall of the tibial cortex (Figure 3).
metastases are a consequence of tumor-induced activation of bone matrix resorption.
Previous studies have shown that [sup.18]F-FDG PET/CT has modest sensitivity for detecting osteoblastic lesions and that [sup.18]F-NaF PET/CT detects both osteoblastic and osteolytic
bone metastases well [10, 23].
However, Ewing's sarcoma can also be distinguished from Garre's osteomyelitis due to producing osteophytes with a "sun ray" appearance, causingbone enlargement too rapidly and causing more osteolytic
reactions in the bone, as well as the occurrence of frequent complications such as facial neuralgia and lip paresthesia [1, 10].
The authors present two rare cases of well DTC without significant histological poor prognosis features presenting as osteolytic
DKK-1 and sclerostin inhibit osteoblast activity by blocking Wnt pathway signaling and thereby contribute to progression of osteolytic
Afterwards, a CT scan of chest and abdomen revealed osteosclerotic and osteolytic
lesions similar to that of skull involving almost the whole skeleton (Figure 2) but not a single clear-cut primary tumor site could be located.
Caption: Figure 1: Plain radiograph showing osteolytic
changes at the medial side of the left iliac bone.