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A disease characterized by avascular necrosis of ossification centers followed by regeneration. Also known as Calvé's disease; Kienböck's disease; Köhler's disease; Osgood-Schlatter disease; Scheuermann's disease.



any one of a group of primarily inflammatory diseases of the subcartilaginous portions of long tubular bones and apophyses of short bones of the skeleton that result from specific suppurative infections, for example, tuberculosis, or—less commonly—nonspecific suppurative infections of bones and joints. Osteochondrosis can be provoked by colds and microtraumas caused by physical overexertion. In severe cases, all the bones and joints may be affected. Noninflammatory changes in bones and joints can also be classified as osteochondroses.

The clinical symptoms of osteochondrosis are pain and limited movements in the affected joints. The disease can be detected by roentgenographic examination, but no specific treatment exists. Rest and immobilization in a functionally correct position serve to prevent bone deformities, while the pain can be diminished by heat applications and treatment in a health resort.

References in periodicals archive ?
The non-traumatic causes of AVN include alcoholism, coagulopathies, systemic chemotherapy, chronic liver disease, corticosteroids, decompression sickness, Gaucher disease, gout, haemoglobinopathy, hyperlipidaemia, idiopathic non-traumatic osteonecrosis, metabolic bone disease, pregnancy, radiation therapy, smoking, systemic lupus erythematosus, DIC, fat embolism syndrome, HIV, deep sea diving, and vasculitis.
Patients with small- or medium-sized Ficat Stage I or II osteonecrosis on radiographs and ARCO Stage I or II on MRI were included in the study.
Transtrochanteric rotational osteotomy of the femoral head for the treatment of osteonecrosis.
Radiographs showed osteonecrosis and fracture of distal femur around femoral prosthesis which also demonstrated femoral component loosening [Figure 5].
The therapies we assessed for the conservative osteonecrosis management included bisphosphonates, prostaglandin agents, enoxaparin, statins, hyperbaric oxygen, extracorporeal shockwave therapy, and pulsed electromagnetic field therapy.
Because early diagnosis and immediate treatment of osteonecrosis is very important, the physician must bear in mind that osteonecrosis might result from impaired microvascular involvement in even NBD.
Bone Therapeutics (EBR: BOTHE) has completed the recruitment of 44 treated patients for the planned interim analysis of the Phase III trial for PREOB as a treatment of osteonecrosis, the company disclosed on Thursday.
Osteonecrosis of the femoral head was first described in 1738 by Munro.
The guidelines also state that, for patients at high risk of fractures, the reduced risk of vertebral fractures associated with bisphosphonate use outweighs the risk of osteonecrosis or atypical femoral fractures.
Additionally, the report provides an overview of key players involved in therapeutic development for Osteonecrosis and features dormant and discontinued projects.
Key Words: Osteonecrosis, osteonecrosis of the jaw, bone metastases, antibone absorptive therapy, bisphosphonates, denosumab.
MAUI, HAWAII -- Patients with systemic lupus erythematosus (SLE) really need to be placed on bone protection therapy as soon as they start on corticosteroids because their risks of steroid-related osteoporosis and osteonecrosis are so high, Dr.