It is rarely associated with other sclerosing bone dysplasias such as melorheostosis and osteopoikilosis
. When two bone dysplasias are found together, they are known as "overlap syndromes" and can be symptomatic.
(also known as Albers-Schonberg disease, spotted bone disease, or osteopathia condensans disseminata) is a rare, usually asymptomatic bone disorder with an incidence of 1 in 50 000.
Germline LEMD3 mutations were found in patients who had melorheostosis associated with Buschke-Ollendroff syndrome (BOS) or Osteopoikilosis
is an autosomal dominant disorder characterized by small round or ovoid radio-opacities appearing in the juxta-articular regions of bone.
Epidemiological, clinical and radiological aspects of osteopoikilosis
. J Bone Joint Surg 1992; 74:504-6.
(OPK) is a benign rare disorder of the endochondral bone, characterized by small multiple osteocondensation lesions, maximum 10 mm, usually found in the long bones of the limbs, hand, foot, pelvis and spine.
These findings are suggestive of osteopoikilosis
. Similar lesions were also present in the contralateral hand and wrist, as well as the pelvis (Fig.
Rarely, multiple lesions are noted, a condition known as osteopoikilosis
. The typical bone island lesion varies from a few millimeters to a centimeter at its largest diameter.
Increased bone density without modifcation of bone shape Osteopetrosis precocious type Generalised AR delayed type Type 1 uniform AD intermediate type Type 2 endobones with renal tubular Generalised AR AR acidosis Similar other types Axial osteosclerosis osteomesopyknosis Focal sclerosis AD AR with bamboo hair in vertebrae/pelvis Pycnodysostosis Generalised AR Osteosclerosis Cortical AD Stanesu type thickening of long bones, defcient facial sinus development Osteopathia striata Radiodense SP XLD isolated with striations on all cranial sclerosis bones with cranial sclerosis Sponastrime Striated AR dysplasia metaphysis Melorheostosis Flowing SP hyperostosis Osteopoikilosis
Radiodense spots AD Mixed sclerosing Combined pattern SP bone dysplasia 2.
Originally described in the early 1900s by Alberg-Schonberg, osteopoikilosis
, or spotted bone disease, is an uncommon, benign bone dysplasia.
(osteopathia condensans disseminate, spotted bone; OPK) is an asymptomatic, rare bone dysplasia.
. The differential diagnosis includes osteoblastic bone metastasis, tuberous sclerosis, mastocytosis, melorheostosis, and osteopathia striata.