ototoxicity

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ototoxicity

[‚ō·tō·täk′sis·əd·ē]
(medicine)
Drug- or chemical-induced damage to the ear resulting in high-frequency hearing loss and tinnitus or disequilibrium.
References in periodicals archive ?
Other causes of SNHL include the use of ototoxic medications and acoustic trauma, which lead to SNHL at higher frequencies (>4 kHz) (11).
Literature have been evidencing the ototoxic and neurotoxic power of some pesticides to both peripheral and central hearing system, and also pointing out the noise of some farming equipment to be the factor that interacting to pesticides may potentiate their effects, causing disturbances in general and hearing health [8,9].
Auditory damage and subsequent hearing loss can be due to military activity such as noise exposure, blast exposure injuries, and ototoxic medications, either in isolation or combination, resulting in a synergistic effect.
Information was collected concerning the presence and timing of rash during pregnancy and on maternal or perinatal risk factors for congenital hearing loss, such as alcohol consumption, familial hearing loss, ototoxic drug exposure, birth trauma, and postnatal infections.
Demographic data, history of either previous disease related to hearing loss, probable symptoms of hearing loss and risk factors for hearing loss (including history of noise overexposure, use of ototoxic drugs) were asked from subjects via an interview.
It is, however, nephrotoxic and ototoxic, but can be administered in a single dose of 500 mg.
Results and Conclusions: With all subjects included, there is insufficient evidence to say that intramuscular interferon-beta 1a is not ototoxic (in relation to nonuse of a disease-modifying therapy) at all frequencies tested except 3000 and 6000 Hz.
In the literature, the risk factors which lead to hearing deficit have been reported to include a familial history of hereditary hearing deficit, low birth weigth, hyperbilirubinemia, use of ototoxic drugs, sepsis, meningitis, low APGAR and presence of mechanical ventilation (12, 13).
These include a system to monitor changes in hearing caused by ototoxic drugs, a telephone-based tinnitus education program, and an online hearing conservation program targeting Veterans and the military.
ii) Neonatal intensive care of more than 5 days or any of the following regardless of length of stay: Extracorporeal Membrane Oxygenation (ECMO) therapy, assisted ventilation, exposure to ototoxic medications or loop diuretics and hyperbilirubinemia that requires exchange transfusion.
Many different types of medications and substances can have ototoxic effects, mainly on the cochlear hair cells (TABLE 2).
The identification of relevant candidate compounds will be further developed as lead drug candidates in noise and ototoxic drug induced in vivo models.