ototoxicity


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ototoxicity

[‚ō·tō·täk′sis·əd·ē]
(medicine)
Drug- or chemical-induced damage to the ear resulting in high-frequency hearing loss and tinnitus or disequilibrium.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The role of deferoxamine in the prevention of gentamicin ototoxicity: a histological and audiological study in guinea pigs.
This mutation was also identified in an Italian family with neuropathy, Parkinsonism and ototoxicity (100) and another Italian family with maternally inherited non syndromic hearing loss (101) and a Chinese subject with auditory neuropathy (102).
Risk factors for ototoxicity include extremes of age (e.g.
Although scientists are still trying to elucidate the precise mechanism(s) of cisplatin-induced sensorineural ototoxicity in humans, animal models provide some insight into the underlying pathophysiology of cisplatin's ototoxicity.
Together the companies will provide GLP auditory testing to evaluate the efficacy, as well as potential ototoxicity of compounds and devices ahead of clinical trials and a potential investigational new drug (IND) and investigational device exemption (IDE) approval.
STS has been studied by cooperative groups in two Phase 3 clinical studies of survival and reduction of ototoxicity, The Clinical Oncology Group Protocol ACCL0431 and SIOPEL 6.
A small molecule that can be taken orally or via an injection, SENS-401 has received Orphan Drug Designation in Europe for the treatment of sudden sensorineural hearing loss, and Orphan Drug Designation from the US FDA for the prevention of platinum-induced ototoxicity in pediatric population.
Indeed, this approval will allow Sensorion to develop SENS-401 for paediatric patients suffering from severe hearing loss (SSNHL) but also in the prevention of ototoxicity caused by cisplatin.
However, there is still risk for ototoxicity in case of tympanic membrane perforation [10].
Ototoxicity may present as cochleotoxicity or vestibulotoxicity, but never both.
Fennec announced a publication in the June 21 issue of the New England Journal of Medicine for STS in the prevention of cisplatin induced ototoxicity in pediatric patients.
Of the nearly 300 implantation cases I had done in 20 years, it was noted that the cause of deafness in 50 percent of the cases were preventable, 32 percent with rubella, while others had meningitis, infection, otitis media and ototoxicity. If we increase awareness on hearing loss, deafness and screening, 50 percent of such cases can be prevented by immunization or other primary preventive measures.