ouabain


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ouabain:

see digitalisdigitalis
, any of several chemically similar drugs used primarily to increase the force and rate of heart contractions, especially in damaged heart muscle. The effects of the drug were known as early as 1500 B.C.
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ouabain

[wä′bī·ən]
(organic chemistry)
C29H44O12·8H2O White crystals that melt with decomposition at 190°C, soluble in water and ethanol; used in medicine.
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The study, which enrolled its first patient in July, is titled Preop Digifab in CABG to Reduce Ouabain Levels and Prevent AKI.
Actions of bufalin and cinobufalin, two bufadienolides respectively more active and less active than ouabain, on ouabain binding and 86Rb uptake by human erythrocytes.
According to the study, the ouabain compound does not affect the cells in testicles that create sperm, so the men would be able to generate new, healthy sperm down the road.
Expectedly, omeprazole (34.5 [micro]g/ mL), but not ouabain (72.8 [micro]g/mL), inhibited the in vitro [H.sup.+]/[K.sup.+]-ATPase activity by 37.54%, when compared to vehicle (1.38 [+ or -] 0.05 [micro]mol iP/mg/min).
Ouabain is known to act by inhibiting Na?ATPase leading to strong inotropic effects on the heart [163].
Inhibition of[Na.sup.+]/[K.sup.+]/ATPase by ouabain was associated with failure of constitution of an efficient trophectoderm tight junctional seal that is required for expansion of the blastocyst cavity and hatching (17).
Cardiac glycosides are found in a diverse group of plants including Digitalis purpurea and Digitalis lanata (Foxgloves), Nerium oleander (Common oleander), Thevetia peruviana (yellow oleander), Convallaria majalis (Lily of the valley), Urginea maritime and Urginea indica (Squill), Strophanthus gratus (ouabain), Apocynum cannabinum (Dogbane), and Cheiranthus cheiri (Wallflower) has resulted in cardiac glycoside poisoning.
Generally, stem cells reside within a special microenvironment or 'niche', which provides factors that regulate the proliferation and differentiation of the stem cell population.23 SSCs expand in the presence of feeder layer cells such as mouse embryonic fibroblast (MEF) cells, Sandos Inbred Mouse (SIM) mouse embryo-derived Thioguanine and Ouabain resistant cells (STO cells) and human embryonic cell- derived fibroblast-like cells (hEFs).24 However, use of xenogeneic orallogeneic feeder cells for culturing human SSCs is associated with risks such as pathogen transmission and viral infection.
Dietary sodium alters airway function by elevating systemic levels of endogenous ouabain that in turn inhibit the Na[sup]+/K[sup]+ pump.
Objective: Ouabain is a plant derived active pharmaceutical ingredient for specific heart diseases.
Cardiac glycosides such as ouabain and proscillaridin were among the most potent compounds in the screen.
Assays were performed with or without 1 mmol Ouabain, a specific inhibitor of [Na.sup.+]-[K.sup.+]-ATPase.