ouabain


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ouabain:

see digitalisdigitalis
, any of several chemically similar drugs used primarily to increase the force and rate of heart contractions, especially in damaged heart muscle. The effects of the drug were known as early as 1500 B.C.
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ouabain

[wä′bī·ən]
(organic chemistry)
C29H44O12·8H2O White crystals that melt with decomposition at 190°C, soluble in water and ethanol; used in medicine.
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References in periodicals archive ?
According to the study, the ouabain compound does not affect the cells in testicles that create sperm, so the men would be able to generate new, healthy sperm down the road.
Therefore Ananda Pharma GmbH developed AnandaCorA, a fast melting tablet formulation of the active substance ouabain.
It can be concluded that decrease tissue sodium also decrease the calcium influx into the cells resulting in vasodilation and by stimulating the ouabain sensitive pump activities and decrease in aldosterone production may contribute in the antihypertensive mechanism of nifedipine.
Ouabain inhibition of gill Na-K ATPase: relationship to active chloride transport.
The Crested Rat appears to be completely immune to ouabain, which is well known for its heart-arresting properties.
These observations are attributed to associations of the Trp460 allele with increased Na+/K+-ATPase activity and renal tubular sodium reabsorption as well as elevated levels of plasma ouabain, a natriuretic hormone that has vasoconstrictive properties (5, 6, 26).
The GTPase activity was reduced in the W07-toxin treated mice enterocytes which was found to be increased in presence of ouabain, a non-specific inhibitor of GTPase.
Neuronal depolarization and release of excitatory amino acid are mimicked by ouabain (32).
Ouabain inhibition of gill Na-K-ATPase: relationship to active chloride transport.
Ouabain binding and potassium transport in young and old populations of human red cells.