The independent Data Safety Monitoring Board (DSMB) notified Mesoblast that an interim analysis showed that the predefined Bayesian futility rule used to determine the probability of the trial's success using the trial's primary endpoint of Day 28 overall response
had been passed.
An overall response
rate of 65 percent in all children at day 28 when MSC-100-IV was used either as last-line or front-line therapy a er steroid failure
An overall response
rate of 65 percent and 62 percent, respectively, in patients with gastrointes nal and liver disease, who have the highest mortality risk
Secondary endpoints include overall survival and overall response
rate, pharmacokinetics, safety and biomarker analyses.
Tenders are invited for this solicitation for professional services is to assist in obtaining weighted behavioral survey data for the high school population by realizing an overall response
rate of 62% or higher, which incorporates both the school response rate and student response rate.
Treatment with the oncolytic immunotherapy talimogene laherparepvec (T-VEC) resulted in significantly longer rates of durable response and overall response
, compared with subcutaneous granulocyte-macrophage colony-stimulating factor (GM-CSF), according to results from the phase III OPTiM trial reported in the Journal of Clinical Oncology.
All women tested had a response in at least one of the time periods with an overall response
Primary endpoints for this study are best overall response
rate assessed by an independent review committee (IRC) using RECIST criteria, and secondary endpoints are best overall response
rate assessed by clinical investigators, duration of response, progression-free survival, overall survival and safety.
Osiris Therapeutics, Columbia, MD, announced that a new study shows Prochymal achieved an overall response
rate of 63% when used as a rescue therapy in children suffering from severe treatment resistant graft vs.
JI: How was the overall response
and feedback from the audience?
The authors were charged with developing recommendations to improve the overall response
of the sector to violence through improved service delivery, increased service co-ordination and enhanced co-ordination of funding and investment strategies.
3 minutes between the time a 911 dispatcher gets a call to the time the dispatcher relays it to the officer - that time is included in the overall response