The trial initiation is informed by the positive results of an independent case series which demonstrated that the use of methotrexate with Krystexxa was well tolerated and led to an improved overall response
. In the trial, 135 adult patients will be randomized to receive methotrexate or placebo for four weeks and then receive treatment with Krystexxa and methotrexate or Krystexxa and placebo for 52 weeks, with the primary endpoint measured at Month 6, followed by a six-month follow-up period.
M2 PHARMA-December 12, 2017-Data from Blueprint Medicines Trial of Avapritinib in Patients with Advanced Systemic Mastocytosis Show Excellent Overall Response
and Disease Control Rates
Japan-based Eisai has dosed its first patient in a clinical trial to explore whether or not the company's eribulin in combination with Halozyme Therapeutics' PEGPH20 can improve overall response
rate in women with advanced breast cancer, it was reported yesterday.
In a research note to investors, White says the updated selinexor with Darzalex data "continues to look good," with efficacy results showing an overall response
rate of 73% in Darzalex naive patients versus the EHA abstract data published last month with an ORR of 77%.
The findings showed a significant improvement in overall response
rate for Xilonix-treated patients versus placebo.
The analyst believes Mirati's KRAS G12Ci has potential to exceed AMG510's 50% overall response
rate in non-small cell lung cancer.
Final results of VE-BASKET for the 22 people with ECD showed a best overall response
rate of 54.5 %.
The firm stated that in the trial Opdivo indicated a consistent statistically significant superiority over docetaxel across all secondary endpoints including overall response
rate and progression-free survival.