overdominance

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overdominance

[¦ō·vər′däm·ə·nəns]
(genetics)
Monohybrid heterosis, that is, the phenotype is being more pronounced in the heterozygote than in either homozygote with respect to a specified pair of alleles.
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Model ACLR (n=229) % CON (n=181) % Codominant G/G 99 43.2 89 49.2 A/G 101 44.1 77 42.5 A/A 29 12.7 15 8.3 Dominant G/G 99 43.2 89 49.2 A/G-A/A 130 56.8 92 50.8 Recessive G/G-A/G 200 87.3 166 91.7 A/A 29 12.7 15 8.3 Overdominant G/G-A/A 128 55.9 104 57.5 A/G 101 44.1 77 42.5 Model OR 95% CI p * Codominant G/G 1.00 0.262/0.469 A/G 0.85 0.56 1.28 A/A 0.58 0.29 1.14 Dominant G/G 1.00 0.231/0.334 A/G-A/A 0.79 0.53 1.16 Recessive G/G-A/G 1.00 0.151/0.306 A/A 0.62 0.32 1.20 Overdominant G/G-A/A 1.00 0.751/0.731 A/G 0.94 0.63 1.39 * after a slash p value adjusted for sex; OR--odds ratio, 95% CI-- confidence intervals Table 3.
In case of four irrigations seedcotton yield also inherited as an overdominant trait as the average degree of dominance [H1AD]1/2=1.3 was greater than unity.
The low frequency of the STK-39 SNP heterozygsity resulted also in an insignificant association with essential hypertension in the dominant (OR = 0.94, p = 0.841), codominant (OR = 0.99, p = 0.987) and overdominant (OR = 0.92, p = 0.772) models of inheritance (Table 3).
Indeed, "[T]here is a recurring fear that an overdominant Southern wing will drag the GOP onto the cliffs of extremism in the same way that the McGovernite wing pulled the Democrats too far to the Left during the 1970s."
Nestle has offered concessions to ease fears it would be overdominant in the US premium ice cream segment.
Furthermore, it is important that presentation and debate involve the whole board and are not solely channelled through an overdominant chief executive.
The actions for the three regulatory QTLs identified from height plasticity were overdominant, that is, the plasticity of the heterozygotes transcended the range of the two homozygotes (see Wu 1997).
The executive's capacity for intimacy can be squeezed out by the overdominant striving for mastery.
The differences of genotypes between the epithelial ovarian cancer patients and the controls were analyzed using SNPStats online software (https://www.snpstats.net/snpstats/start.htm), which provided the genotypic association including codominant, dominant, recessive, or overdominant genetic models.
Model Genotype Cases (%) Controls (%) OR (95% CI) Codominant A/A 24.7 31.1 1 A/G 45.1 46.5 1.22 (0.84-1.78) G/G 30.3 22.5 1.70 (1.11-2.61) Dominant A/A 24.7 31.1 1 A/G-G/G 75.3 68.9 1.38 (0.97-1.96) Recessive A/A-A/G 69.7 775 1 G/G 30.3 22.5 1.50 (1.05-2.14) Overdominant A/A-G/G 54.9 53.5 1 A/G 45.1 46.5 0.95 (0.69-1.29) Log-additive -- -- -- 1.30 (1.05-1.61) Model Genotype P value AIC BIC Codominant A/A 0.049 * 871.3 884.6 A/G G/G Dominant A/A 0.073 872.1 881 A/G-G/G Recessive A/A-A/G 0.026 * 870.3 879.2 G/G Overdominant A/A-G/G 0.73 875.2 884 A/G Log-additive -- 0.015 * 869.4 878.3 OR: odds ratio; 95% CI: 95% confidence intervals; AIC: Akaike's information criterion; BIC: Bayesian information criterion; * P < 0.05.
This is in contrast to the classical HLA molecules that possess high frequencies of polymorphisms with crucial functional differences, maintained by overdominant selection [3].