The plant contains the powerful alkaloid Berberine and the lesser alkalines Oxyacanthine
and Berbamine; tannins, gum, resin and starch.
The presence of protoberberine and bisbenzylisoquinoline alkaloids like berberine, oxyberberine, palmatine, oxyacanthine, berbamine, and tetrandrine are mainly responsible for the diverse pharmacological properties of the genus [4, 5].
Tetrandrine and oxyacanthine have been found to have antioxidant, antidiabetic, antimicrobial, anticancer, antihair loss, anti-inflammatory, antiallergic, anticalcium channel blocker, antihypertensive, sleep enhancing, and anticancer effects [11-13].
Thus keeping in mind the broad spectrum of pharmacological properties of Berberis and its bisbenzyl isoquinoline alkaloids, we explored Berberis glaucocarpa crude extract, subfractions, and oxyacanthine (1) and tetrandrine (2) for their in-vitro antiurease enzyme properties against jack-bean urease enzyme and molecular docking studies.
orthobotrys roots including pakistanine, 1-O-methylpakistanine, pakistanamine, aromoline, chitraline, kalashine and oxyacanthine
(Hussain et al., 1981).
It also contains smaller amounts of berbamine and jatrorrhizine and even lesser amounts of palmatine, oxyacanthine, and other alkaloids .
Gradientelution HPLC of the alkaloid residue and reference compounds (berberine, berbamine, palmatine, jatrorrhizine, and oxyacanthine) was carried out on a Hewlett Packard liquid chromatograph (HPLC 1100) equipped with a quaternary solvent pump, an autosampler, a thermostat, and a photodiode array detector.
Plant contains Berberine, jatrorrhizine, o-methylcorydine-N-oxide palmitine, oxyacanthine
. Hyperaccumulator and antimicrobial activities of Berberis chitria have been exploited (Singh et.
The major components of Berberis are berberine, a yellow colored isoquineoline alkaloid, beramine and oxyacanthine
, which are both white alkaloids, along with phytosterin, gum and sugar.
Berberis aquifolium contains berberine, berbamine, oxyacanthine
bealei, include berberine, palmatine, magnoflorine, jatrorrhizine, oxyacanthine
, berbamine, columbamine, isotertrandrine and epiberberine (Ji et al.
Oregon Grape Root (Mahonia aquifolium): The chemical components of Mahonia aquifolium (Ma) consist of isoquinolin and isoquinoline derivates including berberine, berbamine, and oxyacanthine
. (67) The traditional use of Ma by North American Indian tribes was for the treatment of appetite loss and debility.