TABLE 3: Oxysterol
levels in control and high fat-cholesterol diets.
PPAR[gamma] expression and role are already linked to trophoblast invasion [8, 9] and downregulation of RXR[alpha] is discussed as protection against apoptosis ; nothing is known about the role of the nuclear oxysterol
receptor--the liver X receptor (LXR)--in miscarriage.
These six genes are GXYLT2, SHQ1 homolog, Saccharomyces cerevisiae (SHQ1), PDZRN3, ADP-ribosylation factor-like 15 (ARL15), oxysterol
binding protein 2 (OSBP2), and mevalonate kinase (MVK).
In contrast to the repression of CYP7A1 transcription by FXR, CYP7A1 is transactivated by the oxysterol
The team of UCLA-led researchers described the antiviral property of the protein, cholesterol-25-hydroxylase (CH25H), an enzyme that converts the cholesterol to an oxysterol
called 25-hydroxycholesterol (25HC), which can permeate a cell's wall and block a virus from getting in.
The INSIGs protein blocks SREBP1 activity when the level of oxysterol
is high (see references in ).
Vujic et al., "Lysosomal cholesterol hydrolysis couples efferocytosis to anti-inflammatory oxysterol
production," Circulation Research, vol.
Laurent et al., "Molecular characterization of oxysterol
binding to the Epstein-Barr Virusinduced gene 2 (GPR183)," Journal of Biological Chemistry, vol.
Keelan, "Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol
induced toxicity," Biochimica et Biophysica Acta, vol.
Ghribi, "Endoplasmic reticulum stress-induced CHOP activation mediates the downregulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol
27-hydroxycholesterol," Cellular Signalling, vol.
Successful heterozygous living donor liver transplantation for an oxysterol
7[alpha]-hydroxylase deficiency in a Japanese patient.
The study, which includes a Simon Fraser University researcher, describes how cholesterol-binding proteins called ORPs may control cell growth in A Detour for Yeast Oxysterol