oxysterol

oxysterol

[‚äk·sē′stir‚ȯl]
(biochemistry)
Oxidized derivative of cholesterol.
References in periodicals archive ?
TABLE 3: Oxysterol levels in control and high fat-cholesterol diets.
PPAR[gamma] expression and role are already linked to trophoblast invasion [8, 9] and downregulation of RXR[alpha] is discussed as protection against apoptosis [4]; nothing is known about the role of the nuclear oxysterol receptor--the liver X receptor (LXR)--in miscarriage.
These six genes are GXYLT2, SHQ1 homolog, Saccharomyces cerevisiae (SHQ1), PDZRN3, ADP-ribosylation factor-like 15 (ARL15), oxysterol binding protein 2 (OSBP2), and mevalonate kinase (MVK).
In contrast to the repression of CYP7A1 transcription by FXR, CYP7A1 is transactivated by the oxysterol receptor, LXR[alpha].
The team of UCLA-led researchers described the antiviral property of the protein, cholesterol-25-hydroxylase (CH25H), an enzyme that converts the cholesterol to an oxysterol called 25-hydroxycholesterol (25HC), which can permeate a cell's wall and block a virus from getting in.
The INSIGs protein blocks SREBP1 activity when the level of oxysterol is high (see references in [33]).
Vujic et al., "Lysosomal cholesterol hydrolysis couples efferocytosis to anti-inflammatory oxysterol production," Circulation Research, vol.
Laurent et al., "Molecular characterization of oxysterol binding to the Epstein-Barr Virusinduced gene 2 (GPR183)," Journal of Biological Chemistry, vol.
Keelan, "Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity," Biochimica et Biophysica Acta, vol.
Ghribi, "Endoplasmic reticulum stress-induced CHOP activation mediates the downregulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol," Cellular Signalling, vol.
The study, which includes a Simon Fraser University researcher, describes how cholesterol-binding proteins called ORPs may control cell growth in A Detour for Yeast Oxysterol Binding Proteins.