p27


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p27

[‚pē‚twen·tē ′sev·ən]
(cell and molecular biology)
A cyclin-dependent kinase inhibitor in normal and neoplastic cells.
References in periodicals archive ?
showed that UDCA treatment reversed the inflammation-related suppression of the cyclin dependent kinase inhibitor p27. However, the expression of p27 and the effects of UDCA in the dysplastic areas were not consistent.
Western blotting was used to measure cyclin-dependent kinase (CDK) inhibitors p21 and p27 that arrest cell cycle.
O gene gag codifica proteinas estruturais internas (p15c, p12, p27 e p10), o gene pol codifica proteinas envolvidas na replicacao viral (Integrase, RT) e o gene env codifica proteinas do envelope viral (gp70 e p15e) (HARTMANN, 2006).
Mediante esta tecnica, se han examinado proteinas como p53, bcl2, C-Myc, Ki 67, Ciclinas, P16 INK4a, p21, p27, [beta]-catenina y MCM en NIC y en CC.
p21WAF1 (p21) and p27KIP1 (p27) are both universal inhibitors of cyclin-dependent kinases and can therefore influence cell cycle or tumor progression.
Objective.--To investigate the utility of Ki-67 and other cell cycle regulatory proteins (S-phase kinase-associated protein 2 [Skp2], p27, and cyclin D1) in the differential diagnosis of mammary vascular lesions.
This suggests that p27 becomes more firmly switched on with age, they report in June 22 Nature.
En un futuro proximo podra determinarse a agresividad de un cancer de prostata con solo analizar los niveles sanguineos de la proteina p27 --muy abundante en la prostata sana--, la cual impide el desarrollo de las celulas malignas.
(More information about the review process is on p27.)
In these circumstances, the roof plane becomes the most significant climatic moderator and as our theoretical study showed at the National Trust (p27), for an office building in the UK to approach carbon neutrality, providing all of its heating, cooling and power requirements on site, a low-rise solution has considerable advantages.
Fred Hutchinson Cancer Research Center (Seattle, WA) has patented an isolated protein designated p27. The p27 protein has an apparent molecular weight of about 27 kD, and is capable of binding to and inhibiting the activation of a cyclin E-Cdk2 complex.
Researchers also provided updates on other potential biomarkrs, including the antiapoptotic protein BAG-1 and the cell cycle regulators p27, cyclin E, and p53.