p53


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p53

[‚pē‚fif·tē′thrē]
(genetics)
A multifunctional tumor suppressor protein consisting of several domains that exhibit a number of biochemical activities and interact with a large variety of cellular and viral proteins; its encoding gene is the most commonly mutated gene in tumor cells.
References in periodicals archive ?
p53 helps with this balancing act in the female embryo by producing normal levels of Xist RNA, part of an intricate molecular process important for X chromosome inactivation.
p53 forward primer was 5'-CAGTCTGGGACAGCC AAGTC-3' and its reverse primer was 5'-CTTCTGTACGGCGG TCTCTC-3'
The key, according to the researchers, is a protein known as PUMA (the acronym for "p53 upregulated modulator of apoptosis"), which works inside mitochondria, the energy hub of cells.
The P53 billion will also be scrutinized by the bicameral conference on the General Appropriations Bill, Andaya said.
The mRNA level of p53 was normalized to [beta]-actin with the [2.sup.-[DELTA][DELTA]Ct] method (20).
Association between p53 Pro72Arg polymorphism and prostate cancer risk: a meta-analysis.
Increasing evidence has indicated that p53 plays a crucial role in the regulation of immune response.
This study was undertaken to observe the expression and association of p53 and grades of p53 in premalignant and malignant cervical lesions and also with their histopathological subtypes.
When the researchers deleted p53 completely, the cells became immortal but quickly developed into bone.
Membranes were probed with primary antibodies against cleaved caspase 3, Bip, [alpha]-tubulin, p53, p21, or [beta]-actin followed by incubation with corresponding horseradish peroxidase-conjugated secondary antibody.
In the article titled "Is p53 Involved in Tissue-Specific Insulin Resistance Formation?" [1], there were a number of language errors, due to publisher error.