p53


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p53

[‚pē‚fif·tē′thrē]
(genetics)
A multifunctional tumor suppressor protein consisting of several domains that exhibit a number of biochemical activities and interact with a large variety of cellular and viral proteins; its encoding gene is the most commonly mutated gene in tumor cells.
References in periodicals archive ?
Apoptosis induction often appears to be related to the production process of P53 protein.
Frequent occurrence of p53 mutations in rhabdomyosarcoma and leiomyosarcoma, but not in fibrosarcoma and malignant neural tumors.
According to the researchers, the function of the p53 gene is critical to finding a way to prevent cells from becoming cancerous, and further research to determine how the p53 gene is activated could lead to better drugs and ways to diagnosis cancer.
This newly discovered function of p53 is surprising, says geneticist Franck Toledo of the Curie Institute's research center in Paris.
The p53 protein, also known as tumor protein 53 (TP53), is a transcription factor that functions as a major tumor suppressor in mammals.
Introgen's biomarkers include the identification of aberrant p53 function by detecting abnormally elevated levels of p53 protein in tumor tissue, a more inclusive indicator of p53 defects than the analysis of p53 mutations.
PFT-[alpha] inhibited apoptotic death of C8 cells, a conventional model for p53 dependent apoptosis induced by DOX, etoposide, taxol, UV light and [gamma]-irradiation [13].
An alternative method to evaluate the p53 gene is the p53 GeneChip[R] (Affymetrix), which uses oligonucleotide microarray technology to detect mutations (29).
Mice with extra p53 developed early signs of old age such as muscle loss, hunched backs, and brittle bones.
P53 was found to be active in the normal cells but inactive in the genetically defective cells.
Patients whose tumors are made up of nondiploid cells and who have abnormal, elevated expression of the tumor-suppressor gene p53 have a markedly worse outlook than patients with diploid cells and normal p53, he said at the combined annual meetings of the Central Association of Obstetricians and Gynecologists.