Apoptosis induction often appears to be related to the production process of P53
Frequent occurrence of p53
mutations in rhabdomyosarcoma and leiomyosarcoma, but not in fibrosarcoma and malignant neural tumors.
According to the researchers, the function of the p53
gene is critical to finding a way to prevent cells from becoming cancerous, and further research to determine how the p53
gene is activated could lead to better drugs and ways to diagnosis cancer.
This newly discovered function of p53
is surprising, says geneticist Franck Toledo of the Curie Institute's research center in Paris.
protein, also known as tumor protein 53 (TP53), is a transcription factor that functions as a major tumor suppressor in mammals.
Introgen's biomarkers include the identification of aberrant p53
function by detecting abnormally elevated levels of p53
protein in tumor tissue, a more inclusive indicator of p53
defects than the analysis of p53
PFT-[alpha] inhibited apoptotic death of C8 cells, a conventional model for p53
dependent apoptosis induced by DOX, etoposide, taxol, UV light and [gamma]-irradiation .
The investigators detected abnormal p53
in 168 patients (22%).
An alternative method to evaluate the p53
gene is the p53
GeneChip[R] (Affymetrix), which uses oligonucleotide microarray technology to detect mutations (29).
Mice with extra p53
developed early signs of old age such as muscle loss, hunched backs, and brittle bones.
was found to be active in the normal cells but inactive in the genetically defective cells.
Patients whose tumors are made up of nondiploid cells and who have abnormal, elevated expression of the tumor-suppressor gene p53
have a markedly worse outlook than patients with diploid cells and normal p53
, he said at the combined annual meetings of the Central Association of Obstetricians and Gynecologists.