p53


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p53

[‚pē‚fif·tē′thrē]
(genetics)
A multifunctional tumor suppressor protein consisting of several domains that exhibit a number of biochemical activities and interact with a large variety of cellular and viral proteins; its encoding gene is the most commonly mutated gene in tumor cells.
References in periodicals archive ?
When the researchers deleted p53 completely, the cells became immortal but quickly developed into bone.
However, as previously observed with other genetic variants of p53, a significant association was present in women in premenopausal age.
Histosections were routinely stained with H and E, p53 immunostaining were also done on the same specimens.
Recent studies have shown that S100B interacts directly with P53 protein and binds to its trans-activation domain as well as its C terminal end, which results in decrease in the P53 level and loss of its tumour suppressing activity.
The report reviews Cellular Tumor Antigen P53 (Tumor Suppressor P53 or Antigen NY-CO-13) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
A lot of Ehrlich carcinoma cells expressed both p53 & Caspase 3 and present predominantly in large blood vessels central veins and less in sinusoids and periportal areas.
Antibodies against cytokeratin 18, p53 upregulated modulator of apoptosis- (PUMA-) [alpha], B-cell lymphoma- (Bcl-) 2, Bcl-2-associated X protein (Bax), and a SIRT1 activity assay kit were obtained from Abcam (Cambridge, UK).
Apoptosis induction often appears to be related to the production process of P53 protein.
For GST pull-down assay (17), 50 [micro]g of GST- WT p53 or GST proteins was mixed with 5 mg of either the MCF7 or MDA-MB-468 cell lysates for 2 hr at 4[degrees]C.
The summary of immuno-staining data and staining intensity of p53 and KI-67 according to LI in Normal, dysplastic and malignant cases is given in Table No 3 and 4 respectively.
In this study, the level of serum p53 in chronic hepatitis and cirrhotic patients following HBV infection is evaluated.