"The consistency with which we were able to induce and maintain tolerance to transplants in nonhuman primates makes us very hopeful that our findings can be confirmed for the benefit of patients in planned clinical trials in
pancreatic islet and living-donor kidney transplantation - it would open an entirely new era in transplantation medicine."
The alcoholism has a major effect on
pancreatic islets cells and their insulin secretion.
Wang et al., "Oxygen environment and islet size are the primary limiting factors of isolated
pancreatic islet survival," PLoS One, vol.
Piemonti, "Alternative transplantation sites for
pancreatic islet grafts," Current Diabetes Reports, vol.
Swenne, "Microcarriers: a new approach to
pancreatic islet cell culture," In Vitro, vol.
Stainier, "Thyroid hormone coordinates
pancreatic islet maturation during the zebrafish larval-to-juvenile transition to maintain glucose homeostasis," Diabetes, vol.
In the pancreatic endocrine portion, ghrelin-ip cells were located among the
pancreatic islet cells, and and the distribution of ghrelin-ip cells was observed mostly at the periphery of the islet, a few ghrelin-ip cells were found in the central portion of
pancreatic islets.
Chronic Oxidative stress as a central mechanism for glucose toxicity in
pancreatic islet Beta cells in diabetes.
MSG-obese rats presented morbid obesity, NAFLD, glucose intolerance, insulin resistance, hyperinsulinemia, hyperleptinemia, and
pancreatic islet hyperfunction (15-17).
Increasing evidence suggests that metabolic stress (glucose, free fatty acids, and human amyloid polypeptide) appears to activate the IL-1 system through the NLRP3 inflammasome in
pancreatic islet [19, 22, 23].