pancreatic juice


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Related to pancreatic juice: intestinal juice, bile

pancreatic juice

(păn'krēăt`ĭk, păng'–), secretions of the exocrine portion of the pancreaspancreas
, glandular organ that secretes digestive enzymes and hormones. In humans, the pancreas is a yellowish organ about 7 in. (17.8 cm) long and 1.5 in. (3.8 cm) wide. It lies beneath the stomach and is connected to the small intestine at the duodenum (see digestive system).
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 into the small intestine. The juice contains a number of important digestive enzymesenzyme,
biological catalyst. The term enzyme comes from zymosis, the Greek word for fermentation, a process accomplished by yeast cells and long known to the brewing industry, which occupied the attention of many 19th-century chemists.
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, including trypsintrypsin,
enzyme that acts to degrade protein; it is often referred to as a proteolytic enzyme, or proteinase. Trypsin is one of the three principal digestive proteinases, the other two being pepsin and chymotrypsin.
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, chymotrypsinchymotrypsin
, proteolytic, or protein-digesting, enzyme active in the mammalian intestinal tract. It catalyzes the hydrolysis of proteins, degrading them into smaller molecules called peptides. Peptides are further split into free amino acids.
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, carboxypeptidase, lipaselipase
, any enzyme capable of degrading lipid molecules. The bulk of dietary lipids are a class called triacylglycerols and are attacked by lipases to yield simple fatty acids and glycerol, molecules which can permeate the membranes of the stomach and small intestine for use by
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, and amylaseamylase
, enzyme having physiological, commercial, and historical significance, also called diastase. It is found in both plants and animals. Amylase was purified (1835) from malt by Anselme Payen and Jean Persoz.
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. Pancreatic juice is alkaline in nature because of a high concentration of bicarbonate ions; this helps to neutralize the acidic gastric juicegastric juice,
thin, strongly acidic (pH varying from 1 to 3), almost colorless liquid secreted by the glands in the lining of the stomach. Its essential constituents are the digestive enzymes pepsin and rennin (see rennet), hydrochloric acid, and mucus.
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 from the stomach. Secretion of pancreatic juice is stimulated by hormones of the duodenum, such as secretin and cholecystokinin, and by nervous impulses through the vagus nerve.

Pancreatic Juice

 

a complex digestive juice secreted by the acinar cells of the pancreas and discharged into the duodenum.

The pancreatic juice is a clear, colorless liquid, alkaline in reaction (pH 8.3–8.6). Its specific gravity is 1.007–1.009. Among the enzymes it contains are trypsin, chymotrypsin, and carboxypeptidase, enzymes which split up proteins; lipase, which splits fats; and amylase and lactase, which break down carbohydrates. Pancreatic juice also contains proteins (mainly globulins), creatinine, urea, uric acid, and some trace elements. The average amount discharged in a healthy person in 24 hours is 1.5–2 liters. The secretion and discharge of the pancreatic juice is regulated by humoral and neural means. Other regulatory agents are secretin—a hormone produced by the acid stomach contents in the mucosa of the small intestine—and the secretory fibers of the vagus and sympathetic nerves. Physiological stimulators of pancreatic-juice flow are hydrochloric and some other acids, bile, and food.

pancreatic juice

[¦pan·krē¦ad·ik ′jüs]
(physiology)
The thick, transparent, colorless secretion of the pancreas.
References in periodicals archive ?
KRAS and guanine nucleotide-binding protein mutations in pancreatic juice collected from the duodenum of patients at high risk for neoplasia undergoing endoscopic ultrasound.
The bicarbonate content is a key reason for the alkalinity of bile and pancreatic juice.
Conventional allele-specific PCR revealed the presence of one or more KRAS mutant alleles in 26 (62%) of 42 samples of pancreatic juice from carcinoma cases.
Another intestinal hormone that stimulates the secretion of pancreatic juice is called pancreozymin.
12 Patients with a long-term inflammation by reflux of pancreatic juice into the biliary tract caused by pancreaticobiliary maljunction was considered impartment in the development of malignant change.
Each patient underwent EUS with radial and linear echoendoscopes as well as pancreatic juice collection for IL-8 concentration.
Our current study protocol involves the collection of blood, stool, and pancreatic juice from these individuals and examining them for different potential tumor markers.
Secretin also stimulates the release of pancreatic juice by the pancreas and bile by the liver, both of which contain bicarbonate (a salt) and change the pH of the duodenum (the first or proximal portion of small intestine) from acid to alkaline, thereby facilitating the action of intestinal digestive enzymes.
Mutant TP53 in duodenal samples of pancreatic juice from patients with pancreatic cancer or high-grade dysplasia.
This atypia can be detected in cytologic preparations from pancreatic juice.
It is thought that the near continuous flow of digesta in ruminants minimizes large diurnal fluctuations in intestinal flow and pancreatic juice secretion that occur in the non-ruminant (Merchen and Church, 1988).
In the preface, the editor notes that this book, "is the first and nearly complete collection of applications of proteomics to analyze various human body fluids, including plasma, serum, urine, cerebrospinal fluid, pleural effusions, bronchoalveolar lavage fluid, sputum, nasal lavage fluid, saliva, pancreatic juice, bile, amniotic fluid, milk, nipple aspirate fluid, seminal fluid, vitreous fluid, dialysate, and ultra-filtrate yielded during renal replacement therapy.