pancreatic juice


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Related to pancreatic juice: intestinal juice, bile

pancreatic juice

(păn'krēăt`ĭk, păng'–), secretions of the exocrine portion of the pancreaspancreas
, glandular organ that secretes digestive enzymes and hormones. In humans, the pancreas is a yellowish organ about 7 in. (17.8 cm) long and 1.5 in. (3.8 cm) wide. It lies beneath the stomach and is connected to the small intestine at the duodenum (see digestive system).
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 into the small intestine. The juice contains a number of important digestive enzymesenzyme,
biological catalyst. The term enzyme comes from zymosis, the Greek word for fermentation, a process accomplished by yeast cells and long known to the brewing industry, which occupied the attention of many 19th-century chemists.
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, including trypsintrypsin,
enzyme that acts to degrade protein; it is often referred to as a proteolytic enzyme, or proteinase. Trypsin is one of the three principal digestive proteinases, the other two being pepsin and chymotrypsin.
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, chymotrypsinchymotrypsin
, proteolytic, or protein-digesting, enzyme active in the mammalian intestinal tract. It catalyzes the hydrolysis of proteins, degrading them into smaller molecules called peptides. Peptides are further split into free amino acids.
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, carboxypeptidase, lipaselipase
, any enzyme capable of degrading lipid molecules. The bulk of dietary lipids are a class called triacylglycerols and are attacked by lipases to yield simple fatty acids and glycerol, molecules which can permeate the membranes of the stomach and small intestine for use by
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, and amylaseamylase
, enzyme having physiological, commercial, and historical significance, also called diastase. It is found in both plants and animals. Amylase was purified (1835) from malt by Anselme Payen and Jean Persoz.
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. Pancreatic juice is alkaline in nature because of a high concentration of bicarbonate ions; this helps to neutralize the acidic gastric juicegastric juice,
thin, strongly acidic (pH varying from 1 to 3), almost colorless liquid secreted by the glands in the lining of the stomach. Its essential constituents are the digestive enzymes pepsin and rennin (see rennet), hydrochloric acid, and mucus.
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 from the stomach. Secretion of pancreatic juice is stimulated by hormones of the duodenum, such as secretin and cholecystokinin, and by nervous impulses through the vagus nerve.

Pancreatic Juice

 

a complex digestive juice secreted by the acinar cells of the pancreas and discharged into the duodenum.

The pancreatic juice is a clear, colorless liquid, alkaline in reaction (pH 8.3–8.6). Its specific gravity is 1.007–1.009. Among the enzymes it contains are trypsin, chymotrypsin, and carboxypeptidase, enzymes which split up proteins; lipase, which splits fats; and amylase and lactase, which break down carbohydrates. Pancreatic juice also contains proteins (mainly globulins), creatinine, urea, uric acid, and some trace elements. The average amount discharged in a healthy person in 24 hours is 1.5–2 liters. The secretion and discharge of the pancreatic juice is regulated by humoral and neural means. Other regulatory agents are secretin—a hormone produced by the acid stomach contents in the mucosa of the small intestine—and the secretory fibers of the vagus and sympathetic nerves. Physiological stimulators of pancreatic-juice flow are hydrochloric and some other acids, bile, and food.

pancreatic juice

[¦pan·krē¦ad·ik ′jüs]
(physiology)
The thick, transparent, colorless secretion of the pancreas.
References in periodicals archive ?
[97] showed that miRNAs could be extracted and detected from pancreatic juice and stool efficiently and that miR-21, miR-155, and miR-216 in stool have the potential of becoming biomarkers for screening PDAC.
Negative Effect of Metabolic Acidosis on Pancreatic Juice, Bile, and the Entire Digestive System
Thus, it appears that once pancreatic juice stasis due to pancreatic duct narrowing is established, AIP develops into severe pancreatic calcification regardless of prior or ongoing treatment.
Song et al., "Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients," BMC Cancer, vol.
DNA was extracted from pancreatic juice with the phenol-chloroform method (33, 36).
371) do not discuss the experiments of Banting and Best, they do discuss how the hormone secretin is produced by the mucous membrane of the intestine and is carried by the blood to the pancreas, where it stimulates the secretion of pancreatic juice. They also give some details of how secretin can be extracted from intestinal tissue: If the wall of the intestine of any animal is ground up with water and then filtered so as to free it of solid particles, the clear fluid so obtained will be found to contain large amounts of secretin; for when the fluid is injected into the blood of another animal, a very abundant secretion of pancreatic juice results.
The two functions of this organ are to create pancreatic juice, which helps digest food, and to produce insulin and glucagon, which control blood sugar levels.
Whereas early work had predominantly focused on the effects of alcohol on the muscle at the surface of the first part of the small intestine (i.e., duodenum), which controls secretions from the liver, pancreas, and gallbladder into the duodenum (i.e., the sphincter of Oddi), and on the pancreatic ducts (see Figure 1), attention has shifted over the past decade to the influence of alcohol on the clusters of secretory cells (i.e., acini) that produce pancreatic juice containing digestive enzymes.
"To diagnose chronic pancreatitis, EUS and pancreatic juice collection for IL-8 concentration can be performed sequentially under the same sedation at the same time," said Dr.
From the histophysiological point of view, BGs should produce an alkaline secretion (pH = 8.0-9.5) (Farkas & Gero) that is capable of, on the one hand, neutralizing the chymo acid that originates in the stomach, and on the other, supporting favorable pH conditions for adequate action by pancreatic juice enzymes (Krause, 2000; Leeson & Leeson, 1977).
The body overproduces thick, sticky, mucus, which blocks the pancreatic ducts and inhibits the flow of pancreatic juice. Food cannot be digested properly without pancreatic juice.
During the ultrasound, she can obtain a sample of the pancreatic juice, and we are analyzing these samples in the research lab to determine if we can identify new markers of early pancreatic cancer.