papaverine


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papaverine

(pəpăv`ərēn), alkaloid found in opiumopium,
substance derived by collecting and drying the milky juice in the unripe seed pods of the opium poppy, Papaver somniferum. Opium varies in color from yellow to dark brown and has a characteristic odor and a bitter taste.
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 that acts as a muscle relaxant and vasodilator. The drug relaxes the smooth muscle of the larger blood vessels and is used to increase the blood supply to the brain or to the heart, as in the treatment of angina pectorisangina pectoris
, condition characterized by chest pain that occurs when the muscles of the heart receive an insufficient supply of oxygen. This results when the arteries that supply the heart muscle with oxygenated blood are narrowed by arteriosclerosis.
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. It is also used in the treatment of some types of blood clot formation and in the treatment of impotence when the condition is caused by a lack of blood flow.

Papaverine

 

an antispasmodic alkaloid that is found in opium. Papaverine is also produced synthetically. It is used in solutions and tablets for treating such spastic conditions as hypertension, angina pectoris, and irritable colon.

papaverine

[pə′pav·ə‚rēn]
(organic chemistry)
C20H21O4N A white, crystalline alkaloid, melting at 147°C; soluble in acetone and chloroform, insoluble in water; used as a smooth muscle relaxant and weak analgesic, usually as the water-soluble hydrochloride salt.
References in periodicals archive ?
(4) reported a successful treatment of a corpus cavernosum abscess with percutaneous aspiration and intravenous antibiotics in a paraplegic man on intracavernous papaverine injection therapy.
No abnormal complication regarding intracavernosal injection or papaverine were observed in 3 hours post injection.
Blackstone et al., "Spinal cord protective strategies during descending and thoracoabdominal aortic aneurysm repair in the modern era: the role of intrathecal papaverine," Journal of Thoracic and Cardiovascular Surgery, vol.
The eight organic extracts (HAN, MAN, HFN, MFN, HAV, MAV, HFV, and MFV), positive control (Papaverine; phosphodiesterase inhibitor), and vehicle (DMSO 1%) were added to the bath in a volume of 100 [micro]L.
Nevertheless, an intolerance to vincamine and papaverine chlorhydrate could not be excluded, as the safety of these drugs has not been studied in birds.
These metabolism results were consistent with the previous plant cell transformation studies on papaverine and isopapaverine.
The unripe seeds of the opium poppy plant contain 20 natural alkaloids, three of which are harvested for clinical use: morphine and codeine for pain management, and papaverine for smooth muscle relaxation.
Vasodilators such as calcium channel blockers, lignocaine or papaverine may be used to improve the flow through the flap, and a tourniquet may facilitate dissection, although our use of these has been inconsistent.
Cervical dilation recorded after 24 hours of Valethamate bromide administration in this study might be due to its neurotropic (anticholinergic) and papaverine like action on cervical smooth muscles.
The main component of this plant is alkaloids compounds such as morphine, codeine, Narceine and Papaverine that are very important in terms of medical treatment [4].
Papaverine has proven useful in improving TIMI flow of the epicardial arteries, but its use has been limited by its association with the occurrence of ventricular arrhythmias, primarily with intracoronary administration [35].
Antispasmodic activity of benzylisoquinoline alkaloids analogous to papaverine. Planta Medica, Stuttgart, v.