Amongst these are relatively rare entities such as bowenoid papulosis
, epidermolytic acanthoma, and verruciform xanthoma, which are underrecognized by surgical pathologists.
The rationale for classifying lymphomatoid papulosis
as a cutaneous lymphoma is its association with other malignant lymphoproliferative disorders; however, some experts hesitate to classify this chronic skin disease as a true malignancy because of its spontaneous resolution and benign clinical course.
Giam, "A case report of clear cell papulosis
and a review of the literature," Annuals of the Academy of Medicine, Singapore, vol.
Koh, "Is it lymphoma or lymphomatoid papulosis
?" Journal of the American Academy of Dermatology, vol.
The primary cutaneous CD30+ lymphoproliferative disorders include Anaplastic large T cell lymphoma/null-cell primary cutaneous type ALCL, lymphomatoid papulosis
(LyP), and borderline cases of the EORTC classification with overlapping features of the other two conditions.5,10 The large atypical lymphoid cells express CD30, which is a 120 kd transmembrane cytokine receptor of the TNF receptor family being preferentially expressed by activated lymphoid cells.
lesions appear as small self-healing papules, with a necrotic center that often appears in clusters and recurs in the same region of the body.
These histologic changes were most consistent with lymphomatoid papulosis
revealed that the number of Ki-67 positive cells within the dermis was significantly higher in stage IIB-IV MF (22.3%) and lymphomatoid papulosis
(26.3%) than stage I-IIA MF (4.3%) and parapsoriasis (6%).
** Understand the characteristic clinical, morphologic, immunophenotypic, cytochemical, and cytogenetic/ molecular features of acute myeloid leukemia, acute lymphoid leukemia, myelodysplastic syndromes, paroxysmal nocturnal hemoglobinemia, multiple myeloma, monoclonal gammopathy of undetermined significance, non-Hodgkin and Hodgkin lymphoma, neuroblastoma, chronic lymphoproliferative disorders, lymphomatoid granulomatosis, posttransplant lymphoproliferative disorder, polymorphic and lymphomatoid papulosis
, and histiocytic disorders.
Conditions resulting in inflammatory hemorrhage include leukocytoclastic or necrotizing vasculitis, although a few nonvasculitic conditions can be associated with palpable purpura and include chronic pigmented purpura, pityriasis lichenoides et varioliformis acuta (PLEVA), lymphomatoid papulosis
, and erythema multiforme.
Otra inusual presentacion clinica en la poblacion VIH infectada es la papulosis
bowenoide, caracterizada por multiples papulas planas, hiperpigmentadas e hiperqueratosicas de curso cronico en el dorso del pene.